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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad21tm1.1Mmk
targeted mutation 1.1, Matthias Merkenschlager
MGI:5293824
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rad21tm1.1Mmk/Rad21tm1.1Mmk
Tg(Cd4-cre)1Cwi/0 		involves: 129 * C57BL/6 MGI:5293828


Genotype
MGI:5293828
cn1
Allelic
Composition		 Rad21tm1.1Mmk/Rad21tm1.1Mmk
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21tm1.1Mmk mutation (0 available); any Rad21 mutation (59 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:175827 )
• double positive thymocyte differentiation is impaired compared to in control mice
• however, double positive thymocyte survival is normal
decreased double-positive T cell number ( J:175827 )
• until 6 weeks of age, intermediate CD4+ CD8lo cells accumulate more slowly than in control mice
decreased CD8-positive, alpha-beta T cell number ( J:175827 )
• until 6 weeks of age, mature CD4+ cells accumulate more slowly than in control mice
abnormal CD4-positive, alpha beta T cell morphology ( J:175827 )
• CD4 single positive thymocytes exhibit abnormal mitotic figures with multiple spindles, chromosome segregation defects and poor survival compared with control cells
decreased CD4-positive, alpha-beta T cell number ( J:175827 )
• until 6 weeks of age, mature CD4+ cells accumulate more slowly than in control mice

hematopoietic system
abnormal T cell differentiation ( J:175827 )
• double positive thymocyte differentiation is impaired compared to in control mice
• however, double positive thymocyte survival is normal
decreased double-positive T cell number ( J:175827 )
• until 6 weeks of age, intermediate CD4+ CD8lo cells accumulate more slowly than in control mice
decreased CD8-positive, alpha-beta T cell number ( J:175827 )
• until 6 weeks of age, mature CD4+ cells accumulate more slowly than in control mice
abnormal CD4-positive, alpha beta T cell morphology ( J:175827 )
• CD4 single positive thymocytes exhibit abnormal mitotic figures with multiple spindles, chromosome segregation defects and poor survival compared with control cells
decreased CD4-positive, alpha-beta T cell number ( J:175827 )
• until 6 weeks of age, mature CD4+ cells accumulate more slowly than in control mice




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory