Phenotypes associated with this allele

• Allele Symbol: Cacna1c^tm5.1Hfm
• Allele Name: targeted mutation 5.1, Franz Hofmann
• Allele ID: MGI:5293799
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1c^tm5.1Hfm/Cacna1c^tm5.1Hfm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5293820

Genotype
MGI:5293820

hm1

• Allelic Composition: Cacna1c^tm5.1Hfm/Cacna1c^tm5.1Hfm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:176723 )

• mice die between birth and P7

cardiovascular system

decreased heart rate ( J:176723 )

• heart beat fails to increase after birth unlike in wild-type mice

• however, heart beat at E15.5 is normal

irregular heartbeat ( J:176723 )

abnormal myocardial fiber physiology ( J:176723 )

• ventricular cardiac muscles exhibit a massive reduction in L-type calcium currents compared with wild-type cells

• contractile force of the ventricular muscle is reduced compared to in wild-type mice