Phenotypes associated with this allele

• Allele Symbol: Glra1^tm2.1Geh
• Allele Name: targeted mutation 2.1, Gregg E Homanics
• Allele ID: MGI:5293667
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glra1^tm2.1Geh/Glra1^tm2.1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL	MGI:5293673

Genotype
MGI:5293673

hm1

• Allelic Composition: Glra1^tm2.1Geh/Glra1^tm2.1Geh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:177106 )

• induced by strychnine

abnormal righting response ( J:177106 )

• after injection with butanol, pentobarbital, ketamine, and flurazepam, mice exhibit increased duration of loss of righting reflex compared with similarly treated wild-type mice

increased startle reflex ( J:177106 )

tremors ( J:177106 )

• muscle tremors

ataxia ( J:177106 )

• rotarod ataxia

impaired coordination ( J:177106 )

• rotarod ataxia

growth/size/body

decreased body weight ( J:177106 )

nervous system

increased susceptibility to pharmacologically induced seizures ( J:177106 )

• induced by strychnine