All Phenotypes Sox9<tm4.1Tlu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox9^tm4.1Tlu
targeted mutation 4.1, Thomas Lufkin
MGI:5293339

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox9^tm4.1Tlu/Sox9^tm4.1Tlu	involves: 129S4/SvJae * 129S4/SvJaeSor * CD-1	MGI:5293348
cn2	Sox9^tm4.1Tlu/Sox9⁺ Tg(Col2a1-cre)1Bhr/0	involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL	MGI:5293349
cn3	Sox9^tm4.1Tlu/Sox9^tm4.1Tlu Tg(Col2a1-cre)1Bhr/0	involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL	MGI:5293350

Allelic Composition	Sox9^tm4.1Tlu/Sox9^tm4.1Tlu
Genetic Background	involves: 129S4/SvJae * 129S4/SvJaeSor * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9^tm4.1Tlu mutation (0 available); any Sox9 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:176950 )

• mice are viable, fertile and of normal phenotype

Allelic Composition	Sox9^tm4.1Tlu/Sox9⁺ Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9^tm4.1Tlu mutation (0 available); any Sox9 mutation (32 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:176950 )

N	• forelimbs are unaffected

abnormal vertebrae development ( J:176950 )

• intermediate premature ossification at E17.5 in the vertebra

• however, the lumbar vertebra exhibit normal ossification

premature endochondral bone ossification ( J:176950 )

• intermediate at E17.5 in the vertebra

• however, the lumbar vertebra exhibit normal ossification

behavior/neurological

hunched posture ( J:176950 )

growth/size/body

decreased body size ( J:176950 )

Allelic Composition	Sox9^tm4.1Tlu/Sox9^tm4.1Tlu Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9^tm4.1Tlu mutation (0 available); any Sox9 mutation (32 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

short humerus ( J:176950 )

short radius ( J:176950 )

short ulna ( J:176950 )

scapular bone hypoplasia ( J:176950 )

abnormal vertebrae development ( J:176950 )

• severe premature ossification at E17.5 in the vertebra

abnormal vertebral body morphology ( J:176950 )

premature endochondral bone ossification ( J:176950 )

• severe at E17.5 in the vertebra

limbs/digits/tail

abnormal forelimb stylopod morphology ( J:176950 )

• foreshortened long bones

short humerus ( J:176950 )

abnormal forelimb zeugopod morphology ( J:176950 )

• foreshortened long bones

short radius ( J:176950 )

short ulna ( J:176950 )

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