Phenotypes associated with this allele

• Allele Symbol: Tcf7l2^em2Nobr
• Allele Name: endonuclease-mediated mutation 2, Marcelo A Nobrega
• Allele ID: MGI:5292673
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf7l2^em2Nobr/Tcf7l2^em2Nobr	involves: CD-1	MGI:5294420
ht2	Tcf7l2^em2Nobr/Tcf7l2^+	involves: CD-1	MGI:5294421

Genotype
MGI:5294420

hm1

• Allelic Composition: Tcf7l2^em2Nobr/Tcf7l2^em2Nobr
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

absent gastric milk in neonates ( J:175874 )

growth/size/body

decreased birth body size ( J:175874 )

homeostasis/metabolism

hypoglycemia ( J:175874 )

• severe at birth

mortality/aging

neonatal lethality, complete penetrance ( J:175874 )

• mice die within 24 hours of birth

Genotype
MGI:5294421

ht2

• Allelic Composition: Tcf7l2^em2Nobr/Tcf7l2⁺
• Genetic Background: involves: CD-1

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:175874 )

N • mice exhibit normal energy expenditure

decreased circulating glucose level ( J:175874 )

• in fasting mice fed a high-fat diet

hypoglycemia ( J:175874 )

• intermediate at birth

decreased circulating insulin level ( J:175874 )

• in fasting mice fed a high-fat diet

improved glucose tolerance ( J:175874 )

• on standard chow or when fed a high-fat diet

behavior/neurological

polyphagia ( J:175874 )

decreased locomotor activity ( J:175874 )

growth/size/body

decreased lean body mass ( J:175874 )

decreased body weight ( J:175874 )

• at 1 to 6 weeks of age

adipose tissue

decreased total body fat amount ( J:175874 )