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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm
targeted mutation 1, David H Gutmann
MGI:5292522
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor+ Not Specified MGI:5292545
cn2
 		Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor+ Not Specified MGI:5292546
cn3
 		Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor+
Tg(GFAP-cre)#Gtm/0 		involves: C57BL/6 * CBA MGI:5292547


Genotype
MGI:5292545
ht1
Allelic
Composition		 Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:176586 )
• indistinguishable from wild-type mice




Genotype
MGI:5292546
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:176586 )
N
• astrocytes transfected with a cre-expressing adenovirus exhibit normal proliferation




Genotype
MGI:5292547
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor+
Tg(GFAP-cre)#Gtm/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(GFAP-cre)#Gtm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:176586 )
N
• mice exhibit normal brain weight
• mice do not develop seizures
abnormal astrocyte physiology ( J:176586 )
• astrocytes exhibit increased mTor signaling-dependent proliferation compared to in control cells

growth/size/body
growth/size/body region phenotype ( J:176586 )
N
• mice exhibit normal body weight




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory