Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(tTA,CMV*1-Rheb,-EGFP)Gtm}
• Allele Name: targeted mutation 1, David H Gutmann
• Allele ID: MGI:5292522
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gt(ROSA)26Sor^tm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor^+	Not Specified	MGI:5292545
cn2	Gt(ROSA)26Sor^tm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor^+	Not Specified	MGI:5292546
cn3	Gt(ROSA)26Sor^tm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor^+ Tg(GFAP-cre)#Gtm/0	involves: C57BL/6 * CBA	MGI:5292547

Genotype
MGI:5292545

ht1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(tTA,CMV*1-Rheb,-EGFP)Gtm}/Gt(ROSA)26Sor⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:176586 )

• indistinguishable from wild-type mice

Genotype
MGI:5292546

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(tTA,CMV*1-Rheb,-EGFP)Gtm}/Gt(ROSA)26Sor⁺
• Genetic Background: Not Specified

nervous system

nervous system phenotype ( J:176586 )

N • astrocytes transfected with a cre-expressing adenovirus exhibit normal proliferation

Genotype
MGI:5292547

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm1(tTA,CMV*1-Rheb,-EGFP)Gtm}/Gt(ROSA)26Sor⁺; Tg(GFAP-cre)#Gtm/0
• Genetic Background: involves: C57BL/6 * CBA

nervous system

nervous system phenotype ( J:176586 )

N • mice exhibit normal brain weight

N • mice do not develop seizures

abnormal astrocyte physiology ( J:176586 )

• astrocytes exhibit increased mTor signaling-dependent proliferation compared to in control cells

growth/size/body

growth/size/body region phenotype ( J:176586 )

N • mice exhibit normal body weight

cellular

abnormal astrocyte physiology ( J:176586 )

• astrocytes exhibit increased mTor signaling-dependent proliferation compared to in control cells