All Phenotypes Rad21l<tm1Amp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rad21l^tm1Amp
targeted mutation 1, Alberto M Pendas
MGI:5292341

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rad21l^tm1Amp/Rad21l^tm1Amp	B6.Cg-Rad21l^tm1Amp	MGI:5566677
hm2	Rad21l^tm1Amp/Rad21l^tm1Amp	involves: 129S6/SvEvTac * C57BL/6NCr	MGI:5292347

Allelic Composition	Rad21l^tm1Amp/Rad21l^tm1Amp
Genetic Background	B6.Cg-Rad21l^tm1Amp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21l^tm1Amp mutation (0 available); any Rad21l mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:205574 )

• defect in telomere-nuclear envelope attachment

Allelic Composition	Rad21l^tm1Amp/Rad21l^tm1Amp
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21l^tm1Amp mutation (0 available); any Rad21l mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased oocyte number ( J:176168 )

azoospermia ( J:176168 )

• mice lack spermatozoa in the epididymides

abnormal male germ cell apoptosis ( J:176168 )

• by stage IV of spermatogenesis

decreased mature ovarian follicle number ( J:176168 )

absent primordial ovarian follicles ( J:176168 )

ovary atrophy ( J:176168 )

ovary fibrosis ( J:176168 )

• fibrotic

small testis ( J:176168 )

abnormal female meiosis ( J:176168 )

• pachytene oocytes exhibit slight defects in synapsis compared to in wild-type cells

abnormal male meiosis ( J:176168 )

• spermatocytes exhibit discontinuous and fragmented stretches of axial and alteral element and deficient synapsis compared to in wild-type cells

• okadaic acid-treated spermatocytes exhibit unattached univalents unlike in similarly treated wild-type spermatocytes

abnormal synaptonemal complex ( J:176168 )

• spermatocytes exhibit discontinuous and fragmented stretches of axial and alteral element and deficient synapsis compared to in wild-type cells

• pachytene oocytes exhibit slight defects in synapsis compared to in wild-type cells

arrest of spermatogenesis ( J:176168 )

• at stage IV

arrest of male meiosis ( J:176168 )

• at zygotene

reduced female fertility ( J:176168 )

• female mice produce fewer pups per litter compared with wild-type female mice

decreased litter size ( J:176168 )

• female mice produce fewer pups per litter compared with wild-type female mice

male infertility ( J:176168 )

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:176168 )

• in spermatocytes

cellular

decreased oocyte number ( J:176168 )

azoospermia ( J:176168 )

• mice lack spermatozoa in the epididymides

abnormal telomere morphology ( J:176168 )

• in spermatocytes, telomere attachement to the nuclear envelope is partially misregulated compared to in wild-type spermatocytes

abnormal male germ cell apoptosis ( J:176168 )

• by stage IV of spermatogenesis

abnormal double-strand DNA break repair ( J:176168 )

• in spermatocytes

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:176168 )

absent primordial ovarian follicles ( J:176168 )

ovary atrophy ( J:176168 )

ovary fibrosis ( J:176168 )

• fibrotic

small testis ( J:176168 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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