Phenotypes associated with this allele

• Allele Symbol: Ptpmt1^tm1.1Jedi
• Allele Name: targeted mutation 1.1, Jack E Dixon
• Allele ID: MGI:5291923
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptpmt1^tm1.1Jedi/Ptpmt1^tm1.1Jedi	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5291951

Genotype
MGI:5291951

cn1

• Allelic Composition: Ptpmt1^tm1.1Jedi/Ptpmt1^tm1.1Jedi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial morphology ( J:176087 )

• mitochondria in mouse embryonic fibroblasts transfected with an adenovirus expressing cre are smaller and fragmented compared to in control mice

abnormal cell physiology ( J:176087 )

• mouse embryonic fibroblasts transfected with an adenovirus expressing cre exhibit increased ATP levels, extracellular acidification rates, and lactate production and reduced cardiolipin, phosphatidylglycerol, and sphingomyelin levels compared with control mice

decreased cell proliferation ( J:176087 )

• in mouse embryonic fibroblasts transfected with an adenovirus expressing cre

abnormal aerobic respiration ( J:176087 )

• basal respiration rates are lower in mouse embryonic fibroblasts transfected with an adenovirus expressing cre compared with control cell