Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-cre/Esr1*)67Csk
• Allele Name: transgene insertion 67, Chugai Pharmaceutical Co, Ltd
• Allele ID: MGI:5291515
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Actb-GFP,-Bmp4)1Csk/0 Tg(CAG-cre/Esr1*)67Csk/0	C57BL/6-Tg(Actb-GFP,-Bmp4)1Csk Tg(CAG-cre/Esr1*)67Csk	MGI:5291625
tg2	Tg(CAG-cre/Esr1*)67Csk/0	C57BL/6-Tg(CAG-cre/Esr1*)67Csk	MGI:5291624

Genotype
MGI:5291625

cn1

• Allelic Composition: Tg(Actb-GFP,-Bmp4)1Csk/0; Tg(CAG-cre/Esr1*)67Csk/0
• Genetic Background: C57BL/6-Tg(Actb-GFP,-Bmp4)1Csk Tg(CAG-cre/Esr1*)67Csk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

albuminuria ( J:173500 )

• albuminuria is markedly increased in mice following induction; increase correlates with mesangial expansion

renal/urinary system

albuminuria ( J:173500 )

• albuminuria is markedly increased in mice following induction; increase correlates with mesangial expansion

abnormal renal glomerulus morphology ( J:173500 )

• expansion of the mesangial matrix and thickening of the glomerular basement membrane (GBM) is observed after tamoxifen induction

glomerulosclerosis ( J:173500 )

• after tamoxifen induction, animals develop glomerulosclerosis

Genotype
MGI:5291624

tg2

• Allelic Composition: Tg(CAG-cre/Esr1*)67Csk/0
• Genetic Background: C57BL/6-Tg(CAG-cre/Esr1*)67Csk

renal/urinary system

renal/urinary system phenotype ( J:173500 )

N • after tamoxifen induction, mice show no observable renal abnormalities resulting from cre expression or translocation