Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14tm3.1(Mapk11)Nbr mutation
(0 available);
any
Mapk14 mutation
(41 available)
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Growth retardation and placenta abnormalities in Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr embryos
mortality/aging
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• none are found alive at birth
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embryo
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• reduced in size at E11.5
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growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation
(5 available);
any
Edil3 mutation
(42 available)
Mapk11tm1Jsca mutation
(0 available);
any
Mapk11 mutation
(35 available)
Mapk14tm2Nbr mutation
(2 available);
any
Mapk14 mutation
(41 available)
Mapk14tm3.1(Mapk11)Nbr mutation
(0 available);
any
Mapk14 mutation
(41 available)
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Cardiac defects in Mapk14tm3.1(Mapk11)Nbr/Mapk14tm2Nbr Edil3Tg(Sox2-cre)1Amc/0 Mapk11tm1Jsca/Mapk11tm1Jsca embryos
mortality/aging
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• present in the expected numbers at E18.5 but none are found at weaning
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cardiovascular system
nervous system
N |
• spina bifida phenotype seen in double null mice is rescued in mice carrying the Mapk14tm3.1(Mapk11)Nbr allele
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation
(5 available);
any
Edil3 mutation
(42 available)
Mapk14tm2Nbr mutation
(2 available);
any
Mapk14 mutation
(41 available)
Mapk14tm3.1(Mapk11)Nbr mutation
(0 available);
any
Mapk14 mutation
(41 available)
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mortality/aging
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• about 30% of mice survive to adulthood
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