All Phenotypes Mapk14<tm3.1(Mapk11)Nbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapk14^{tm3.1(Mapk11)Nbr}
targeted mutation 3.1, Angel R Nebreda
MGI:5288509

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^{tm3.1(Mapk11)Nbr}	Not Specified	MGI:5288514
cn2	Mapk11^tm1Jsca/Mapk11^tm1Jsca Mapk14^tm2Nbr/Mapk14^{tm3.1(Mapk11)Nbr} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5288513
cn3	Mapk14^tm2Nbr/Mapk14^{tm3.1(Mapk11)Nbr} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: C57BL/6 * CBA	MGI:5288515

Allelic Composition	Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^{tm3.1(Mapk11)Nbr}
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14^{tm3.1(Mapk11)Nbr} mutation (0 available); any Mapk14 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Growth retardation and placenta abnormalities in Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^{tm3.1(Mapk11)Nbr} embryos

mortality/aging

prenatal lethality, complete penetrance ( J:176023 )

• none are found alive at birth

embryo

embryonic growth retardation ( J:176023 )

• at E11.5

decreased placental labyrinth size ( J:176023 )

• reduced in size at E11.5

abnormal trophoblast layer morphology ( J:176023 )

• thicker at E11.5

growth/size/body

embryonic growth retardation ( J:176023 )

• at E11.5

Allelic Composition	Mapk11^tm1Jsca/Mapk11^tm1Jsca Mapk14^tm2Nbr/Mapk14^{tm3.1(Mapk11)Nbr} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (44 available)
Mapk11^tm1Jsca mutation (0 available); any Mapk11 mutation (30 available)
Mapk14^tm2Nbr mutation (2 available); any Mapk14 mutation (43 available)
Mapk14^{tm3.1(Mapk11)Nbr} mutation (0 available); any Mapk14 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cardiac defects in Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/0 Mapk11^tm1Jsca/Mapk11^tm1Jsca embryos

mortality/aging

postnatal lethality, complete penetrance ( J:176023 )

• present in the expected numbers at E18.5 but none are found at weaning

cardiovascular system

ventricular septal defect ( J:176023 )

nervous system

nervous system phenotype ( J:176023 )

N	• spina bifida phenotype seen in double null mice is rescued in mice carrying the Mapk14^{tm3.1(Mapk11)Nbr} allele

Allelic Composition	Mapk14^tm2Nbr/Mapk14^{tm3.1(Mapk11)Nbr} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (44 available)
Mapk14^tm2Nbr mutation (2 available); any Mapk14 mutation (43 available)
Mapk14^{tm3.1(Mapk11)Nbr} mutation (0 available); any Mapk14 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:176023 )

• about 30% of mice survive to adulthood

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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