Phenotypes associated with this allele

• Allele Symbol: Cert1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:5287775
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cert1^tm1a(KOMP)Wtsi/Cert1^tm1a(KOMP)Wtsi	C57BL/6N-Cert1^tm1a(KOMP)Wtsi/Wtsi	MGI:5630985
ht2	Cert1^tm1a(KOMP)Wtsi/Cert1^+	C57BL/6N-Cert1^tm1a(KOMP)Wtsi/Wtsi	MGI:5705973

Genotype
MGI:5630985

hm1

• Allelic Composition: Cert1^{tm1a(KOMP)Wtsi}/Cert1^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Cert1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0855_2_H11

Data Sources

IMPC Data for Cert1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

persistent right dorsal aorta ( J:239583 )

DMDD

persistent trigeminal artery ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

abnormal umbilical vein topology ( J:239583 )

DMDD

abnormal pectinate muscle morphology ( J:239583 )

DMDD

persistent truncus arteriosus ( J:239583 )

DMDD

double outlet right ventricle ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

placenta hemorrhage ( J:261316 )

• hemorrhagic areas/blood pools are seen in the E14.5 placenta

craniofacial

abnormal nasal cavity morphology ( J:239583 )

DMDD

embryo

abnormal umbilical vein topology ( J:239583 )

DMDD

placenta hemorrhage ( J:261316 )

• hemorrhagic areas/blood pools are seen in the E14.5 placenta

abnormal placenta morphology ( J:261316 )

• branching morphology defect at E9.5

• reduced cellular density of placenta at E14.5

• fibrotic/necrotic areas in the placenta at E14.5

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

small placenta ( J:261316 )

• small placenta at E14.5

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment at E9.5

placenta necrosis ( J:261316 )

• necrotic areas in the placenta at E14.5

growth/size/body

abnormal nasal cavity morphology ( J:239583 )

DMDD

fetal growth retardation ( J:239583 )

DMDD

heterochrony ( J:239583 )

DMDD

hearing/vestibular/ear

abnormal semicircular canal morphology ( J:239583 )

DMDD

limbs/digits/tail

absent tibia ( J:239583 )

DMDD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 , J:261316 )

IMPC - WTSI (J:211773)

MGI

• fewer than the expected numbers of mice are seen at P14 (J:261316)

muscle

abnormal pectinate muscle morphology ( J:239583 )

DMDD

nervous system

abnormal forebrain morphology ( J:239583 )

DMDD

respiratory system

abnormal nasal cavity morphology ( J:239583 )

DMDD

skeleton

absent tibia ( J:239583 )

DMDD

abnormal cervical rib ( J:239583 )

DMDD

decreased cervical vertebrae number ( J:239583 )

DMDD

abnormal vertebral arch morphology ( J:239583 )

DMDD

fusion of vertebral arches ( J:239583 )

DMDD

fusion of vertebral bodies ( J:239583 )

DMDD

vision/eye

aphakia ( J:239583 )

DMDD

abnormal optic cup morphology ( J:239583 )

DMDD

Genotype
MGI:5705973

ht2

• Allelic Composition: Cert1^{tm1a(KOMP)Wtsi}/Cert1⁺
• Genetic Background: C57BL/6N-Cert1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0855_2_H11

Data Sources

IMPC Data for Cert1

hematopoietic system

decreased mean corpuscular hemoglobin ( J:211773 )

♀

IMPC - WTSI