Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btnl1tm1(KOMP)Mbp mutation
(2 available);
any
Btnl1 mutation
(30 available)
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hematopoietic system
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• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut
• Normal TCRVgamma7- IEL number in the gut
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• significantly increased TCRbeta+ CD8alpha+ intraepithelial lymphocyte (IEL) level in the gut
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immune system
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• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut
• Normal TCRVgamma7- IEL number in the gut
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• significantly increased TCRbeta+ CD8alpha+ intraepithelial lymphocyte (IEL) level in the gut
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btnl1tm1(KOMP)Mbp mutation
(2 available);
any
Btnl1 mutation
(30 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation
(30 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(tetO-Btnl1)#Ahay mutation
(0 available)
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hematopoietic system
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• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut with or without doxycycline administration
• almost total loss of TCRVgamma7GL2+ IELs in the gut with or without doxycycline administration
• normal CD122hi TCRVgamma7+ IELs (most also Ki67+) in the gut after doxycycline administration
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immune system
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• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut with or without doxycycline administration
• almost total loss of TCRVgamma7GL2+ IELs in the gut with or without doxycycline administration
• normal CD122hi TCRVgamma7+ IELs (most also Ki67+) in the gut after doxycycline administration
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hematopoietic system
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• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut
|
immune system
|
|
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btnl1tm1(KOMP)Mbp mutation
(2 available);
any
Btnl1 mutation
(30 available)
Tg(tetO-Btnl1)#Ahay mutation
(0 available)
Tg(Vil-rtTA2*M2)1Rsmi mutation
(0 available)
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hematopoietic system
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• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut with or without doxycycline administration from age 11 weeks
• almost total loss of TCRVgamma7GL2+ IELs in the gut with or without doxycycline administration from age 11 weeks
• normal CD122hi Lag3hi Thy1- TCRVgamma7+ IELs (most also Ki67+) in the gut after doxycycline administration from age 11 weeks
• normal TCRVgamma7+ and TCRVgamma7GL2+ IEL cell numbers in the gut after doxycycline administration from age 5 or 21 days
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immune system
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• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut with or without doxycycline administration from age 11 weeks
• almost total loss of TCRVgamma7GL2+ IELs in the gut with or without doxycycline administration from age 11 weeks
• normal CD122hi Lag3hi Thy1- TCRVgamma7+ IELs (most also Ki67+) in the gut after doxycycline administration from age 11 weeks
• normal TCRVgamma7+ and TCRVgamma7GL2+ IEL cell numbers in the gut after doxycycline administration from age 5 or 21 days
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Analysis Tools