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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp2r1atm2.1Wltr
targeted mutation 2.1, Gernot Walter
MGI:5287375
Summary 3 genotypes


Genotype
MGI:5287440
hm1
Allelic
Composition		 Ppp2r1atm2.1Wltr/Ppp2r1atm2.1Wltr
Genetic
Background		 FVB.129-Ppp2r1atm2.1Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm2.1Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:175748 )
• mice are viable




Genotype
MGI:5287436
ht2
Allelic
Composition		 Ppp2r1atm2.1Wltr/Ppp2r1a+
Genetic
Background		 FVB.129-Ppp2r1atm2.1Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm2.1Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

respiratory system
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates




Genotype
MGI:5287438
ht3
Allelic
Composition		 Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr
Genetic
Background		 FVB.129-Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm1.2Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
Ppp2r1atm2.1Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung adenoma incidence ( J:175748 )
• in benzopyrene-treated mice
increased lung adenocarcinoma incidence ( J:175748 )
• in benzopyrene-treated mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

respiratory system
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung adenoma incidence ( J:175748 )
• in benzopyrene-treated mice
increased lung adenocarcinoma incidence ( J:175748 )
• in benzopyrene-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory