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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp2r1atm1.1Wltr
targeted mutation 1.1, Gernot Walter
MGI:5287252
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppp2r1atm1.1Wltr/Ppp2r1atm1.2Wltr
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA * FVB/NCrl MGI:5287435


Genotype
MGI:5287435
cn1
Allelic
Composition		 Ppp2r1atm1.1Wltr/Ppp2r1atm1.2Wltr
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA * FVB/NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm1.1Wltr mutation (1 available); any Ppp2r1a mutation (41 available)
Ppp2r1atm1.2Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:175748 )
• mice die 6 days after tamoxifen treatment

behavior/neurological
ataxia ( J:175748 )
• tamoxifen-treated mice exhibit difficulty walking compared with control mice
hunched posture ( J:175748 )
• in tamoxifen-treated mice

growth/size/body
weight loss ( J:175748 )
• in tamoxifen-treated mice beyond the initial drop associated with tamoxifen treatment alone




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory