About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arrdc4tm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:5286528
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arrdc4tm1(KOMP)Vlcg/Arrdc4tm1(KOMP)Vlcg involves: C57BL/6N * C57BL/6NTac MGI:5810097


Genotype
MGI:5810097
hm1
Allelic
Composition		 Arrdc4tm1(KOMP)Vlcg/Arrdc4tm1(KOMP)Vlcg
Genetic
Background		 involves: C57BL/6N * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arrdc4tm1(KOMP)Vlcg mutation (0 available); any Arrdc4 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:236091 )
• mutant mouse embryonic fibroblasts (MEFs) show a ~30% reduction in extracellular vesicle (EV) release relative to wild-type MEFs
• in gut explants cultures, homozygotes exhibit normal levels of DMT1 (divalent metal ion transporter) released in gut EVs but show a significantly reduced protein concentration of EVs released from gut EVs relative to wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory