Analysis Tools
endocrine/exocrine glands
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• some characteristic protein bands are absent and mass spectrometry identified several normally ER resident proteins in the milk
• absence of alpha casein protein and reduction in the amount of beta and gamma casein in the milk
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• concentration of calcium is reduced by about 90% compared to wild-type controls
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• concentration of phosphate is reduced by about 90% compared to wild-type controls
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• overall amount of milk secreted is reduced
• pups nursed by homozygous dams appear emaciated by 6 days of age and show growth restriction
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integument
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• some characteristic protein bands are absent and mass spectrometry identified several normally ER resident proteins in the milk
• absence of alpha casein protein and reduction in the amount of beta and gamma casein in the milk
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• concentration of calcium is reduced by about 90% compared to wild-type controls
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• concentration of phosphate is reduced by about 90% compared to wild-type controls
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• overall amount of milk secreted is reduced
• pups nursed by homozygous dams appear emaciated by 6 days of age and show growth restriction
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homeostasis/metabolism
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• concentration of calcium is reduced by about 90% compared to wild-type controls
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• concentration of phosphate is reduced by about 90% compared to wild-type controls
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