All Phenotypes Padi4<tm1.1Kmow> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Padi4^tm1.1Kmow
targeted mutation 1.1, Kerri A Mowen
MGI:5285854

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Padi4^tm1.1Kmow/Padi4^tm1.1Kmow	involves: BALB/cJ * C57BL/6	MGI:5285855
cn2	Padi4^tm1.1Kmow/Padi4^tm1.1Kmow Tg(CMV-cre)1Cgn/0	involves: BALB/cJ * C57BL/6	MGI:5451198

Allelic Composition	Padi4^tm1.1Kmow/Padi4^tm1.1Kmow
Genetic Background	involves: BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi4^tm1.1Kmow mutation (2 available); any Padi4 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal neutrophil physiology ( J:174934 )

• neutrophils lack histone deimination unlike wild-type cells

decreased susceptibility to Orthomyxoviridae infection ( J:174934 )

• influenza-infected mice exhibit decreased weight loss compared with similarly treated wild-type mice

• however, influenza-infected mice exhibit normal survival, neutrophil recruitment into the lung, lung viral titers, and pro-inflammatory cytokine levels

growth/size/body

decreased susceptibility to weight loss ( J:174934 )

• influenza-infected mice exhibit decreased weight loss compared with similarly treated wild-type mice

hematopoietic system

abnormal neutrophil physiology ( J:174934 )

• neutrophils lack histone deimination unlike wild-type cells

Allelic Composition	Padi4^tm1.1Kmow/Padi4^tm1.1Kmow Tg(CMV-cre)1Cgn/0
Genetic Background	involves: BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi4^tm1.1Kmow mutation (2 available); any Padi4 mutation (40 available)
Tg(CMV-cre)1Cgn mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:190651 )

N	• bone marrow-derived mast cells exhibit normal ATP-stimulated citrullination

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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