Phenotypes associated with this allele

• Allele Symbol: Glo1^{tm1a(KOMP)Mbp}
• Allele Name: targeted mutation 1a, Mouse Biology Program, UC Davis
• Allele ID: MGI:5285709
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glo1^tm1a(KOMP)Mbp/Glo1^tm1a(KOMP)Mbp	C57BL/6N-Glo1^tm1a(KOMP)Mbp	MGI:6280432

Genotype
MGI:6280432

hm1

• Allelic Composition: Glo1^{tm1a(KOMP)Mbp}/Glo1^{tm1a(KOMP)Mbp}
• Genetic Background: C57BL/6N-Glo1^{tm1a(KOMP)Mbp}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavioral despair ( J:251413 )

• homozygotes exhibit a significant increase in immobility time during the tail suspension test, indicating increased depression-like behavior

decreased anxiety-related response ( J:251413 )

• homozygotes show a significant increase in distance travelled, stay period in center zone, and center zone entries in the open field test relative to wild-type controls

• homozygotes make significantly more transitions between light and dark areas in the light-dark box test than wild-type controls

homeostasis/metabolism

abnormal metabolism ( J:251413 )

• homozygotes show a 2-fold increase of MG-H1 levels, an advanced glycation end product (AGE) derived from methylglyoxal (MG) in liver homogenates relative to wild-type controls

• however, no differences in MG-H1, argpyrimidine (another AGE derived from MG), pentosidine (an AGE derived from ribose), carboxymethyl lysine (an AGE derived from glyoxal), or total glutathione (GSH) levels are observed in brain homogenates