About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lmnb2tm1.1Sgy
targeted mutation 1.1, Stephen G Young
MGI:5285673
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy
Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5285675
cn2
 		Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5285682


Genotype
MGI:5285675
cn1
Allelic
Composition		 Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy
Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnb1tm1.1Sgy mutation (1 available); any Lmnb1 mutation (38 available)
Lmnb2tm1.1Sgy mutation (1 available); any Lmnb2 mutation (27 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:174963 )
N
• mice are born at Mendelian frequency and survive for over 2 years

integument
integument phenotype ( J:174963 )
N
• keratinocytes exhibit normal proliferation
• mice exhibit normal skin and hair
abnormal keratinocyte morphology ( J:174963 )
• keratinocytes exhibit an increase in misshapen cell nuclei and nuclear blebs in culture compared with wild-type cells
• however, no polyploidy is observed




Genotype
MGI:5285682
cn2
Allelic
Composition		 Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnb2tm1.1Sgy mutation (1 available); any Lmnb2 mutation (27 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:174963 )
N
• mice are born at Mendelian frequency and survive for over 2 years




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory