Phenotypes associated with this allele

• Allele Symbol: Nes^tm1Nagy
• Allele Name: targeted mutation 1, Andras Nagy
• Allele ID: MGI:5285585
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nes^tm1Nagy/Nes^tm1Nagy	either: (involves: 129S6/SvEvTac * C57BL/6NCr) or (involves: 129S6/SvEvTac * C57BL/6NCr * ICR)	MGI:5285586

Genotype
MGI:5285586

hm1

• Allelic Composition: Nes^tm1Nagy/Nes^tm1Nagy
• Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6NCr) or (involves: 129S6/SvEvTac * C57BL/6NCr * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:175241 )

N • no gross defects are detected in the morphology of the brain

abnormal neuromuscular synapse morphology ( J:175241 )

• in newborn and adult mice, an increase in the number of acetylcholine receptor clusters is seen and these clusters occupy a larger muscle territory in the diaphragm

• the endplate bandwidth is broadened and the nerve length is significantly increased

behavior/neurological

behavior/neurological phenotype ( J:175241 )

N • no defects are detected in grip strength or balance

impaired coordination ( J:175241 )

• lower average latency to fall off a rotarod