Phenotypes associated with this allele

• Allele Symbol: Myh9^{tm6.1(EGFP/MYH9*)Rsad}
• Allele Name: targeted mutation 6.1, Robert S Adelstein
• Allele ID: MGI:5285571
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh9^tm6.1(EGFP/MYH9*)Rsad/Myh9^tm6.1(EGFP/MYH9*)Rsad	involves: 129S4/SvJae * BALB/cJ * C57BL/6	MGI:5499745
ht2	Myh9^tm6.1(EGFP/MYH9*)Rsad/Myh9^+	involves: 129S4/SvJae * BALB/cJ * C57BL/6	MGI:5499743

Genotype
MGI:5499745

hm1

• Allelic Composition: Myh9^{tm6.1(EGFP/MYH9*)Rsad}/Myh9^{tm6.1(EGFP/MYH9*)Rsad}
• Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:175367 )

• mice die at E11.5

embryo

embryonic growth retardation ( J:175367 )

• at E10.5

decreased embryo size ( J:175367 )

• at E10.5

abnormal placenta fetal blood space morphology ( J:175367 )

• more compact with fewer maternal and fetal blood vessel spaces

abnormal placenta intervillous maternal lacunae morphology ( J:175367 )

• more compact with fewer maternal and fetal blood vessel spaces

growth/size/body

embryonic growth retardation ( J:175367 )

• at E10.5

decreased embryo size ( J:175367 )

• at E10.5

Genotype
MGI:5499743

ht2

• Allelic Composition: Myh9^{tm6.1(EGFP/MYH9*)Rsad}/Myh9⁺
• Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

hematopoietic system

increased megakaryocyte cell number ( J:175367 )

• in the bone marrow and spleen

abnormal neutrophil morphology ( J:175367 )

• contain Myh9 aggregates

abnormal platelet morphology ( J:175367 )

• increased diameter

thrombocytopenia ( J:175367 )

• macrothrombocytopenia

homeostasis/metabolism

abnormal blood coagulation ( J:175367 )

• reduced clot retraction

increased bleeding time ( J:175367 )

immune system

abnormal neutrophil morphology ( J:175367 )

• contain Myh9 aggregates