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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ryr2tm1.1Swch
targeted mutation 1.1, S R Wayne Chen
MGI:5285537
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ryr2tm1.1Swch/Ryr2+ involves: 129S1/Sv * 129X1/SvJ * Black Swiss MGI:5285545
ht2
 		Ryr2tm1.1Swch/Ryr2tm2.1Swch involves: 129S1/Sv * 129X1/SvJ * Black Swiss MGI:5605479


Genotype
MGI:5285545
ht1
Allelic
Composition		 Ryr2tm1.1Swch/Ryr2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm1.1Swch mutation (0 available); any Ryr2 mutation (330 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
ventricular tachycardia ( J:174541 )
• mice treated with caffeine and epinephrine exhibit increased ventricular compared with similarly treated wild-type mice

homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:174541 )
• mice treated with caffeine and epinephrine exhibit increased ventricular compared with similarly treated wild-type mice




Genotype
MGI:5605479
ht2
Allelic
Composition		 Ryr2tm1.1Swch/Ryr2tm2.1Swch
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm1.1Swch mutation (0 available); any Ryr2 mutation (330 available)
Ryr2tm2.1Swch mutation (0 available); any Ryr2 mutation (330 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiovascular system physiology ( J:214434 )
• mice are resistant to catecholaminergic polymorphic ventricular tachycardia induced by the administration of caffeine and epinephrine




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory