Phenotypes associated with this allele

• Allele Symbol: Tdg^tm1.1Abc
• Allele Name: targeted mutation 1.1, Alfonso Bellacosa
• Allele ID: MGI:5285105
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tdg^tm1.1Abc/Tdg^tm1.1Abc	B6.129-Tdg^tm1.1Abc	MGI:5285111

Genotype
MGI:5285111

hm1

• Allelic Composition: Tdg^tm1.1Abc/Tdg^tm1.1Abc
• Genetic Background: B6.129-Tdg^tm1.1Abc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:174772 )

• mice are resorbed between E12.5 and E13.5

cardiovascular system

abnormal carotid artery morphology ( J:174772 )

• abnormal vasculogenesis and angiogenesis

abnormal coronary artery morphology ( J:174772 )

• abnormal angiogenesis

abnormal angiogenesis ( J:174772 )

• generalized with altered branching of the internal carotid and coronaries

abnormal dorsal aorta morphology ( J:174772 )

• abnormal vasculogenesis

abnormal vasculogenesis ( J:174772 )

• in the dorsal aorta, carotid arteries, and branchial arteries

myocardium hypoplasia ( J:174772 )

thin myocardium ( J:174772 )

abnormal cardiac outflow tract development ( J:174772 )

• mice exhibit outflow tract septation defects unlike wild-type mice

• mice exhibit severely hyperplastic and bulky outflow tract compared with wild-type mice

abnormal heart development ( J:174772 )

abnormal heart right ventricle morphology ( J:174772 )

• underdeveloped

pericardial edema ( J:174772 )

hemorrhage ( J:174772 )

• mice exhibit diffuse hemorrhagic lesions unlike wild-type mice

hemopericardium ( J:174772 )

liver hemorrhage ( J:174772 )

embryo

pharyngeal arch hypoplasia ( J:174772 )

embryonic growth arrest ( J:174772 )

• at E11.5

cellular

abnormal DNA methylation ( J:174772 )

• hypermethylation of CpG island

abnormal mismatch repair ( J:174772 )

• hypermethylation of CpG island

limbs/digits/tail

abnormal limb development ( J:174772 )

• delayed

nervous system

abnormal telencephalon development ( J:174772 )

• prominent telencephalic vesicles

craniofacial

pharyngeal arch hypoplasia ( J:174772 )

homeostasis/metabolism

hemopericardium ( J:174772 )

pericardial edema ( J:174772 )

abnormal mismatch repair ( J:174772 )

• hypermethylation of CpG island

liver/biliary system

liver hemorrhage ( J:174772 )

muscle

myocardium hypoplasia ( J:174772 )

thin myocardium ( J:174772 )