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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam17tm1Rain
targeted mutation 1, Elaine Raines
MGI:5284875
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adam17tm1Rain/Adam17tm1Rain involves: C57BL/6 MGI:5284895


Genotype
MGI:5284895
hm1
Allelic
Composition		 Adam17tm1Rain/Adam17tm1Rain
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1Rain mutation (0 available); any Adam17 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enhanced leukocyte tethering or rolling ( J:174865 )
• in a model of sterile peritonitis irradiated, wild-type mice reconstituted with fetal liver cells exhibit accelerated neutrophil recruitment compared to in wild-type mice reconstituted with wild-type cells
• in vivo, irradiated wild-type mice reconstituted with fetal liver cells exhibit decreased leukocyte rolling velocity and increased adhesion compared to in wild-type mice reconstituted with wild-type cells

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:174865 )
• irradiated wild-type mice reconstituted with fetal liver cells fail to exhibit an increase in peritoneal neutrophils in response to treatment with hydroxamate inhibitor unlike similarly treated wild-type mice reconstituted with wild-type cells

cellular
enhanced leukocyte tethering or rolling ( J:174865 )
• in a model of sterile peritonitis irradiated, wild-type mice reconstituted with fetal liver cells exhibit accelerated neutrophil recruitment compared to in wild-type mice reconstituted with wild-type cells
• in vivo, irradiated wild-type mice reconstituted with fetal liver cells exhibit decreased leukocyte rolling velocity and increased adhesion compared to in wild-type mice reconstituted with wild-type cells

hematopoietic system
enhanced leukocyte tethering or rolling ( J:174865 )
• in a model of sterile peritonitis irradiated, wild-type mice reconstituted with fetal liver cells exhibit accelerated neutrophil recruitment compared to in wild-type mice reconstituted with wild-type cells
• in vivo, irradiated wild-type mice reconstituted with fetal liver cells exhibit decreased leukocyte rolling velocity and increased adhesion compared to in wild-type mice reconstituted with wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory