Phenotypes associated with this allele

• Allele Symbol: Tnfaip8^{Gt(IST13629C1)Tigm}
• Allele Name: gene trap IST13629C1, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:5178061
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfaip8^Gt(IST13629C1)Tigm/Tnfaip8^Gt(IST13629C1)Tigm	involves: C57BL/6N	MGI:5770277
cx2	Tnfaip8^Gt(IST13629C1)Tigm/Tnfaip8^Gt(IST13629C1)Tigm Tnfaip8l1^em1Huwa/Tnfaip8l1^em1Huwa	involves: C57BL/6 * C57BL/6N	MGI:7568796

Genotype
MGI:5770277

hm1

• Allelic Composition: Tnfaip8^{Gt(IST13629C1)Tigm}/Tnfaip8^{Gt(IST13629C1)Tigm}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:223320 )

N • untreated mice exhibit normal lymphoid organs

increased susceptibility to induced colitis ( J:223320 )

• DSS-treated mice exhibit increased weight loss, colon length and weight, disease activity, bacterial invasion of the colon, colonic epithelial cell apoptosis and mortality compared with wild-type mice

• transplant experiments demonstrate non-hematopoietic cells exacerbate colitis

increased neutrophil cell number ( J:223320 )

• in the blood and colon of DSS-treated mice

small spleen ( J:223320 )

• in DSS-treated mice

increased circulating interleukin-17 level ( J:223320 )

• in DSS-treated mice

increased circulating interleukin-6 level ( J:223320 )

• in DSS-treated mice

increased interleukin-1 beta secretion ( J:223320 )

• in the colon of DSS-treated mice

increased interleukin-17 secretion ( J:223320 )

• in the colon of DSS-treated mice

increased interleukin-6 secretion ( J:223320 )

• in the colon of DSS-treated mice

digestive/alimentary system

digestive/alimentary phenotype ( J:223320 )

N • untreated mice exhibit normal intestines

increased enterocyte apoptosis ( J:223320 )

• in the colon of DSS-treated mice

abnormal colon morphology ( J:223320 )

• increased reduction in colon length and weight DSS-treated mice

increased susceptibility to induced colitis ( J:223320 )

• DSS-treated mice exhibit increased weight loss, colon length and weight, disease activity, bacterial invasion of the colon, colonic epithelial cell apoptosis and mortality compared with wild-type mice

• transplant experiments demonstrate non-hematopoietic cells exacerbate colitis

growth/size/body

increased susceptibility to weight loss ( J:223320 )

• in DSS-treated mice

homeostasis/metabolism

increased circulating interleukin-17 level ( J:223320 )

• in DSS-treated mice

increased circulating interleukin-6 level ( J:223320 )

• in DSS-treated mice

cellular

increased enterocyte apoptosis ( J:223320 )

• in the colon of DSS-treated mice

hematopoietic system

increased neutrophil cell number ( J:223320 )

• in the blood and colon of DSS-treated mice

small spleen ( J:223320 )

• in DSS-treated mice

Genotype
MGI:7568796

cx2

• Allelic Composition: Tnfaip8^{Gt(IST13629C1)Tigm}/Tnfaip8^{Gt(IST13629C1)Tigm}; Tnfaip8l1^em1Huwa/Tnfaip8l1^em1Huwa
• Genetic Background: involves: C57BL/6 * C57BL/6N

behavior/neurological

hunched posture ( J:342074 )

• mice exhibit a hunched posture at 1 year of age

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:342074 )

• inflammation in the lamina propria is occasionally organized into de novo lymphoid follicles

• lamina propria has increased frequency of Th17 cells

• the frequency of total CD45+ immune cells and MHC class II+CD19+ B lymphocytes is increased within the mucosa

abnormal large intestine crypts of Lieberkuhn morphology ( J:342074 )

• colons show elongation of colonic crypts

abnormal colon morphology ( J:342074 )

• multinucleated giant cells are detected in the colon

decreased colon length ( J:342074 )

• 1-year-old mice have shorter colons

rectal prolapse ( J:342074 )

• mice begin to develop rectal prolapse by 40 weeks of age, and by 52 Weeks of age, about 50% of mice develop disease with rectal prolapse

colitis ( J:342074 )

• about 50% of mice develop spontaneous chronic colitis by 52 weeks of age

• colitis severity is variable and penetrance is incomplete

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:342074 )

• colons show elongation of colonic crypts

growth/size/body

decreased body size ( J:342074 )

• mice show growth retardation, especially after 16 weeks of age and exhibit reduced body size at 1 year of age

hematopoietic system

increased leukocyte cell number ( J:342074 )

• increase in circulating inflammatory leukocytes

increased T-helper 17 cell number ( J:342074 )

• lamina propria has increased frequency of Th17 cells

decreased spleen weight ( J:342074 )

• 1-year-old mice have decreased spleen weight

immune system

colitis ( J:342074 )

• about 50% of mice develop spontaneous chronic colitis by 52 weeks of age

• colitis severity is variable and penetrance is incomplete

increased leukocyte cell number ( J:342074 )

• increase in circulating inflammatory leukocytes

increased T-helper 17 cell number ( J:342074 )

• lamina propria has increased frequency of Th17 cells

decreased spleen weight ( J:342074 )

• 1-year-old mice have decreased spleen weight

integument

abnormal coat appearance ( J:342074 )

• mice exhibit massy hair on the head and upper back at 1 year of age