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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fostm6.1Wag
targeted mutation 6.1, Erwin F Wagner
MGI:5142241
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fostm6.1Wag/Fostm6.1Wag involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5142264
cx2
 		Egfrwa2/Egfr+
Fostm6.1Wag/Fostm6.1Wag
Tg(KRT5-SOS1)892A6Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:5142268


Genotype
MGI:5142264
hm1
Allelic
Composition		 Fostm6.1Wag/Fostm6.1Wag
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fostm6.1Wag mutation (0 available); any Fos mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is increased compared to in wild-type cultures
increased susceptibility to endotoxin shock ( J:175064 )
• LPS-treated mice exhibit increased TNF-alpha, IL6, and IL10 serum levels compared with similarly treated wild-type mice

skeleton
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is increased compared to in wild-type cultures

homeostasis/metabolism

hematopoietic system
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is increased compared to in wild-type cultures

cellular
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is increased compared to in wild-type cultures




Genotype
MGI:5142268
cx2
Allelic
Composition		 Egfrwa2/Egfr+
Fostm6.1Wag/Fostm6.1Wag
Tg(KRT5-SOS1)892A6Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (2 available); any Egfr mutation (88 available)
Fostm6.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin papilloma incidence ( J:175064 )
• papillomas are larger than in Tg(KRT5-SOS1)892A6Mka mice

integument
increased skin papilloma incidence ( J:175064 )
• papillomas are larger than in Tg(KRT5-SOS1)892A6Mka mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory