All Phenotypes Cav1<tm1.1Aia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cav1^tm1.1Aia
targeted mutation 1.1, Alexander I Agoulnik
MGI:5141474

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cav1^tm1.1Aia/Cav1^tm1.1Aia	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5141497
cx2	Cav1^tm1.1Aia/Cav1^tm1.1Aia crsp/crsp	involves: 129S7/SvEvBrd * C57BL/6J * FVB	MGI:5141498
cx3	Cav1^tm1.1Aia/Cav1^tm1.1Aia crsp/+	involves: 129S7/SvEvBrd * C57BL/6J * FVB	MGI:5141500
cx4	Cav1^tm1.1Aia/Cav1^tm1.1Aia Rxfp2^tm1Aia/Rxfp2⁺	involves: 129S7/SvEvBrd * C57BL/6J * FVB	MGI:5141501

Allelic Composition	Cav1^tm1.1Aia/Cav1^tm1.1Aia
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cav1^tm1.1Aia mutation (0 available); any Cav1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:174719 )

N	• mice are fertile

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 6% of mice

uterus cyst ( J:174719 )

• in 19% of mice

abnormal uterus physiology ( J:174719 )

• endometrial glandular epithelium in mice with cysts exhibit increased proliferation compared to in wild-type mice

neoplasm

neoplasm ( J:174719 )

N	• mice do not develop endometrial cancer or metastases

endocrine/exocrine glands

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 6% of mice

growth/size/body

ovary cyst ( J:174719 )

• in 6% of mice

uterus cyst ( J:174719 )

• in 19% of mice

Allelic Composition	Cav1^tm1.1Aia/Cav1^tm1.1Aia crsp/crsp
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cav1^tm1.1Aia mutation (0 available); any Cav1 mutation (29 available)
crsp mutation (0 available); any crsp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 8% of mice

uterus cyst ( J:174719 )

• in 62% of mice

neoplasm

neoplasm ( J:174719 )

N	• mice do not develop endometrial cancer or metastases

endocrine/exocrine glands

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 8% of mice

growth/size/body

ovary cyst ( J:174719 )

• in 8% of mice

uterus cyst ( J:174719 )

• in 62% of mice

Allelic Composition	Cav1^tm1.1Aia/Cav1^tm1.1Aia crsp/+
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:174719 )

N	• female mice are fertile

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 4% of mice

uterus cyst ( J:174719 )

• in 55% of mice

neoplasm

neoplasm ( J:174719 )

N	• mice do not develop endometrial cancer or metastases

endocrine/exocrine glands

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 4% of mice

growth/size/body

ovary cyst ( J:174719 )

• in 4% of mice

uterus cyst ( J:174719 )

• in 55% of mice

Allelic Composition	Cav1^tm1.1Aia/Cav1^tm1.1Aia Rxfp2^tm1Aia/Rxfp2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cav1^tm1.1Aia mutation (0 available); any Cav1 mutation (29 available)
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:174719 )

N	• female mice are fertile

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

uterus cyst ( J:174719 )

• in 24% of mice at 5 to 7 months

• in 58% of mice at 11 to 13 months

abnormal uterus physiology ( J:174719 )

• endometrial glandular epithelium in mice with cysts exhibit increased proliferation compared to in wild-type mice

neoplasm

neoplasm ( J:174719 )

N	• mice do not develop endometrial cancer or metastases

endocrine/exocrine glands

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

growth/size/body

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

uterus cyst ( J:174719 )

• in 24% of mice at 5 to 7 months

• in 58% of mice at 11 to 13 months

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