Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cdc42tm1.1Yizh targeted mutation 1.1, Yi Zheng MGI:5140986 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 weeks, mice exhibit decreased fractional shortening and ejection fraction compared with wild-type mice
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• at 12 weeks, mice exhibit decreased fractional shortening and ejection fraction compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 4 weeks of age
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• at 4 weeks of age, mice exhibit decreased cardiac stroke volume compared with wild-type mice and single heterozygotes
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• at 4 weeks of age, mice exhibit decreased cardiac function (reduced left ventricle ejection fraction, fractional shortening of the ventricular chamber, volume of ejected blood with each heart beat, and cardiac output) compared with wild-type mice or single heterozygotes
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• mice exhibit prolonged QT and QTc intervals compared with wild-type mice
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• at 4 weeks of age, mice exhibit decreased cardiac function (reduced left ventricle ejection fraction, fractional shortening of the ventricular chamber, volume of ejected blood with each heart beat, and cardiac output) compared with wild-type mice or single heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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