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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fezf1tm1.1Bche
targeted mutation 1.1, Bin Chen
MGI:5140793
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fezf1tm1.1Bche/Fezf1tm1.1Bche involves: CD-1 MGI:5140794
cx2
 		Fezf1tm1.1Bche/Fezf1tm1.1Bche
Fezf2tm1Skm/Fezf2tm1Skm 		involves: 129 * CD-1 MGI:5140795
cx3
 		Fezf1tm1.1Bche/Fezf1+
Fezf2tm1Skm/Fezf2tm1Skm 		involves: 129 * CD-1 MGI:5140796


Genotype
MGI:5140794
hm1
Allelic
Composition		 Fezf1tm1.1Bche/Fezf1tm1.1Bche
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf1tm1.1Bche mutation (1 available); any Fezf1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:174726 )
• olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

craniofacial
abnormal olfactory sensory neuron morphology ( J:174726 )
• olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

respiratory system
abnormal olfactory sensory neuron morphology ( J:174726 )
• olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:174726 )
• olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

growth/size/body
abnormal olfactory sensory neuron morphology ( J:174726 )
• olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice




Genotype
MGI:5140795
cx2
Allelic
Composition		 Fezf1tm1.1Bche/Fezf1tm1.1Bche
Fezf2tm1Skm/Fezf2tm1Skm
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf1tm1.1Bche mutation (1 available); any Fezf1 mutation (31 available)
Fezf2tm1Skm mutation (0 available); any Fezf2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
abnormal olfactory sensory neuron morphology ( J:174726 )
• as in Fezf1tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

craniofacial
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
abnormal olfactory sensory neuron morphology ( J:174726 )
• as in Fezf1tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

respiratory system
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
abnormal olfactory sensory neuron morphology ( J:174726 )
• as in Fezf1tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:174726 )
• as in Fezf1tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice

growth/size/body
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
• mice exhibit vomeronasal organ degeneration compared with wild-type mice
abnormal olfactory sensory neuron morphology ( J:174726 )
• as in Fezf1tm1.1Bche homozygotes, olfactory sensory neuron axonal projections fail to reach the olfactory bulb and instead form fasciculated bundles unlike in wild-type mice




Genotype
MGI:5140796
cx3
Allelic
Composition		 Fezf1tm1.1Bche/Fezf1+
Fezf2tm1Skm/Fezf2tm1Skm
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf1tm1.1Bche mutation (1 available); any Fezf1 mutation (31 available)
Fezf2tm1Skm mutation (0 available); any Fezf2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice

craniofacial
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice

respiratory system
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice

growth/size/body
abnormal vomeronasal sensory neuron morphology ( J:174726 )
• mice lack vomeronasal organ neurons unlike wild-type mice
absent vomeronasal organ ( J:174726 )
• at P0, the vomeronasal organ is absent unlike in wild-type mice
small vomeronasal organ ( J:174726 )
• at E13.5, the vomeronasal organ is smaller than in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory