All Phenotypes F2<tm2Jld> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

F2^tm2Jld
targeted mutation 2, Jay L Degen
MGI:5140722

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F2^tm2Jld/F2^tm2Jld	B6.129P2-F2^tm2Jld	MGI:5140787
ht2	F2^tm2Jld/F2⁺	B6.129P2-F2^tm2Jld	MGI:5140788
ht3	F2^tm2Jld/F2⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA/2J	MGI:5140789

Allelic Composition	F2^tm2Jld/F2^tm2Jld
Genetic Background	B6.129P2-F2^tm2Jld

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2^tm2Jld mutation (0 available); any F2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:174629 )

• some mice die between a few days of birth and remaining mice die within 2 weeks

integument

subcutaneous hemorrhage ( J:174629 )

• subcutaneous bleeding within the head and neck region

cardiovascular system

internal hemorrhage ( J:174629 )

• overt hemorrhage in the abdomen

subcutaneous hemorrhage ( J:174629 )

• subcutaneous bleeding within the head and neck region

Allelic Composition	F2^tm2Jld/F2⁺
Genetic Background	B6.129P2-F2^tm2Jld

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2^tm2Jld mutation (0 available); any F2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating protein level ( J:174629 )

• LPS-treated mice exhibit a modest decrease in activated protein C serum and thrombin-antithrombin levels compared with similarly treated wild-type mice

decreased susceptibility to induced thrombosis ( J:174629 )

• following FeCl3 injury, mice exhibit extended time to complete vessel occlusion compared with similarly treated wild-type mice

increased bleeding time ( J:174629 )

immune system

decreased susceptibility to endotoxin shock ( J:174629 )

• LPS-treated mice exhibit a modest decrease in activated protein C serum and thrombin-antithrombin levels compared with similarly treated wild-type mice

• however, LPS-treated mice exhibit no survival advantage

Allelic Composition	F2^tm2Jld/F2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2^tm2Jld mutation (0 available); any F2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to induced arthritis ( J:174629 )

• mice treated with collagen to induce arthritis exhibit reduced histologic features of inflammatory joint disease (inflammatory cell infiltrate, synovial hyperplasia, edema, pannus formation, and cartilage/bone degradation) compared with similarly treated wild-type mice

decreased synovial pannus formation ( J:174629 )

skeleton

decreased susceptibility to induced arthritis ( J:174629 )

decreased synovial pannus formation ( J:174629 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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