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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epb41l3tm1Bhat
targeted mutation 1, Manzoor A Bhat
MGI:5140703
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Epb41l3tm1Bhat/Epb41l3tm1Bhat Not Specified MGI:5140709
cn2
 		Epb41l3tm1Bhat/Epb41l3tm1.1Bhat
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: FVB/N MGI:5140710


Genotype
MGI:5140709
hm1
Allelic
Composition		 Epb41l3tm1Bhat/Epb41l3tm1Bhat
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epb41l3tm1Bhat mutation (0 available); any Epb41l3 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:173383 )
• homozygotes born in expected numbers and ratios
• no obvious behavioral or developmental defects




Genotype
MGI:5140710
cn2
Allelic
Composition		 Epb41l3tm1Bhat/Epb41l3tm1.1Bhat
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epb41l3tm1.1Bhat mutation (0 available); any Epb41l3 mutation (45 available)
Epb41l3tm1Bhat mutation (0 available); any Epb41l3 mutation (45 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal paranode morphology ( J:173383 )
• accumulation of smooth endoplasmic reticulum in nodal-paranodal regions
abnormal paranodal axoglial junction morphology ( J:173383 )
• septate junction septa in sciatic nerves become more diffuse, most lacking electron dense granules at 1 month of age
• septa in sciatic nerves are diffuse and fuzzy at 3 months
• axolemma becomes detached from the myelin loops where septa are missing in the spinal cord




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory