Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angpt1tm1.1Seq mutation
(0 available);
any
Angpt1 mutation
(35 available)
Angpt1tm1.2Seq mutation
(0 available);
any
Angpt1 mutation
(35 available)
Tg(Nphs1-cre)1Seq mutation
(0 available)
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renal/urinary system
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• mice treated with doxycycline since E16.5 and exposed to STZ to induce diabetes exhibit accelerated glomerular damage compared with similarly treated control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angpt1tm1.1Seq mutation
(0 available);
any
Angpt1 mutation
(35 available)
Angpt1tm1.2Seq mutation
(0 available);
any
Angpt1 mutation
(35 available)
Tg(Pdgfrb-cre)#Rha mutation
(0 available)
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renal/urinary system
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• mice treated with doxycycline since E16.5 and exposed to STZ to induce diabetes exhibit accelerated glomerular damage compared with similarly treated control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angpt1tm1.2Seq mutation
(0 available);
any
Angpt1 mutation
(35 available)
Kdrtm2.1Jrt mutation
(2 available);
any
Kdr mutation
(71 available)
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Loss of trabeculations in the heart of E9.5 and E10.5 Angpt1tm1.2Seq/Angpt1tm1.2Seq Kdrtm2.1Jrt/Kdr+ embryos
mortality/aging
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• mice die between E9.5 and E12.5
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cardiovascular system
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• at E10.5, mice exhibit an increase in vasculature in the hindbrain compared with wild-type mice
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• at E10.5, mice exhibit vascular defects with fusion of large diameter vessels and absence of patterning compared with wild-type mice
• however, pericyte coverage is normal
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• at E 9.5, mice exhibit heart defects and loss of heart trabeculation unlike wild-type mice
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embryo
nervous system
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• at E10.5, mice exhibit an increase in vasculature in the hindbrain compared with wild-type mice
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growth/size/body
Analysis Tools
