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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Homer1tm2Mhd
targeted mutation 2, Marlin H Dehoff
MGI:5086112
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Homer1tm2Mhd/Homer1tm2Mhd involves: 129S1/Sv * 129X1/SvJ MGI:5461827
hm2
 		Homer1tm2Mhd/Homer1tm2Mhd involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5086117


Genotype
MGI:5461827
hm1
Allelic
Composition		 Homer1tm2Mhd/Homer1tm2Mhd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Homer1tm2Mhd mutation (0 available); any Homer1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal nociception after inflammation ( J:191366 )
• formalin-treated mice exhibit a decreased response to pain during the second phase, but not the first phase, compared with wild-type mice




Genotype
MGI:5086117
hm2
Allelic
Composition		 Homer1tm2Mhd/Homer1tm2Mhd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Homer1tm2Mhd mutation (0 available); any Homer1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal miniature excitatory postsynaptic currents ( J:174500 )
• pyramidal neurons exhibit an increased in the average amplitude of miniature excitatory postsynaptic currents (EPSCs) compared with wild-type neurons
• treatment with TTX or bicuculline does not alter mEPSC amplitudes unlike in similarly treated wild-type mice
• following maximal electroconvulsive seizure, mice fail to exhibit a decrease in mEPSC amplitudes unlike wild-type mice
• application of Bay and MPEP does not increase mEPSC amplitude unlike in wild-type mice

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:174500 )
• treatment with TTX or bicuculline does not alter mEPSC amplitudes unlike in similarly treated wild-type mice
• application of Bay and MPEP does not increase mEPSC amplitude unlike in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory