Analysis Tools
hearing/vestibular/ear
| N |
• hair cells with abnormal stereocilliary bundles are maintained for at least 4 weeks after birth
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• narrow and elongated basal region of stereocilia
• protrusions from apical surface of hair cells
• reduced amplitude of saturated mechanotransduction currents after stimulation with a stiff glass probe
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• severely disorganized and many stereocilia abnormally thick and large at age P5
• many normally shaped bundles with degenerative changes, some with only slight abnormalities, at age P5
• many fragmented bundles with thin and elongated stereocilia, sometimes with few stereocilia remaining, at age P5
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• some fragmented bundles with few, thin and elongated, stereocilia remaining, at age P5
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• severely disorganized and many stereocilia abnormally thick and large at age P5
• some rounded bundle-shape (vs normal V- shape), some with signs of degeneration, at age P5
• many elongated but normally shaped bundles at age P5
• some fragmented bundles with some thin and elongated stereocilia at age P5
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• defects in hair bundle polarity: more variable bundle orientation at age P2
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• many fragmented bundles with thin and elongated stereocilia, sometimes with few stereocilia remaining, at age P5
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• across 0-45 kHz frequency spectrum in 4-week old mice
• across 8-32 kHz frequency spectrum according to increased DPOAE threshold in 4-week old mice
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• according to lack of auditory brain stem response (ABR) to broadband click stimuli in 4-week old mice
• deaf across 8-32 kHz frequency spectrum according to lack of ABR to pure tones in 4-week old mice
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nervous system
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• narrow and elongated basal region of stereocilia
• protrusions from apical surface of hair cells
• reduced amplitude of saturated mechanotransduction currents after stimulation with a stiff glass probe
|
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• severely disorganized and many stereocilia abnormally thick and large at age P5
• many normally shaped bundles with degenerative changes, some with only slight abnormalities, at age P5
• many fragmented bundles with thin and elongated stereocilia, sometimes with few stereocilia remaining, at age P5
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• some fragmented bundles with few, thin and elongated, stereocilia remaining, at age P5
|
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• severely disorganized and many stereocilia abnormally thick and large at age P5
• some rounded bundle-shape (vs normal V- shape), some with signs of degeneration, at age P5
• many elongated but normally shaped bundles at age P5
• some fragmented bundles with some thin and elongated stereocilia at age P5
|
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• defects in hair bundle polarity: more variable bundle orientation at age P2
|
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• many fragmented bundles with thin and elongated stereocilia, sometimes with few stereocilia remaining, at age P5
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