Phenotypes associated with this allele

• Allele Symbol: Aurkb^tm1.1Mama
• Allele Name: targeted mutation 1.1, Marcos Malumbres
• Allele ID: MGI:5056426
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aurkb^tm1.1Mama/Aurkb^tm1.1Mama	involves: 129/Sv * C57BL/6 * CD-1 * SJL	MGI:5056445

Genotype
MGI:5056445

hm1

• Allelic Composition: Aurkb^tm1.1Mama/Aurkb^tm1.1Mama
• Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:173575 )

• about 25% of MEFs infected with viral cre show accumulation of alpha-tubulin asters that are either connected to chromosomes in multipolar cells or not connected to chromosomes

abnormal cell nucleus morphology ( J:173575 )

• micronuclei are seen in MEFs infected with viral cre

increased cell nucleus count ( J:173575 )

• accumulation of cells with multiple nuclei in MEFs infected with viral cre

polyploidy ( J:173575 )

• MEFs infected with viral cre accumulate as 4N or greater than 4N DNA content cells

abnormal mitosis ( J:173575 )

• absence of cytokinesis in MEFs infected with viral cre

• multiple microtubule organizing centers

• decrease in the duration of mitotic arrest induced by nocodazole in MEFs infected with viral cre compared to control cells

abnormal mitotic spindle morphology ( J:173575 )

• monopolar spindles

increased fibroblast apoptosis ( J:173575 )

• in MEFs infected with viral cre