Phenotypes associated with this allele

• Allele Symbol: Hax1^tm1.1Gach
• Allele Name: targeted mutation 1.1, Gernot Achatz
• Allele ID: MGI:5056144
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hax1^tm1.1Gach/Hax1^tm1.1Gach	involves: BALB/c	MGI:5056195

Genotype
MGI:5056195

hm1

• Allelic Composition: Hax1^tm1.1Gach/Hax1^tm1.1Gach
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:174159 )

• death occurs around 10-14 days of age

growth/size/body

decreased body size ( J:174159 )

decreased body weight ( J:174159 )

postnatal growth retardation ( J:174159 )

behavior/neurological

impaired coordination ( J:174159 )

• loss of motor coordination by 3-4 weeks of age

skeleton

fragile skeleton ( J:174159 )

• femora and tibiae are more fragile than in controls

hematopoietic system

thymus hypoplasia ( J:174159 )

• cell mass significantly reduced

decreased bone marrow cell number ( J:174159 )

• cell mass significantly reduced

decreased hematopoietic stem cell number ( J:174159 )

• stem cell pool is reduced about 40%

abnormal lymphocyte morphology ( J:174159 )

decreased pro-B cell number ( J:174159 )

• pre-pro and pro-B cells reduced in bone marrow

abnormal B cell number ( J:174159 )

increased follicular B cell number ( J:174159 )

• absolute numbers are somewhat increased

decreased B cell number ( J:174159 )

• 62% reduction in B220+ cells in bone marrow

• reduced in the spleen

• newly formed B cells are reduced in number in bone marrow

decreased immature B cell number ( J:174159 )

decreased transitional stage T1 B cell number ( J:174159 )

decreased transitional stage T2 B cell number ( J:174159 )

decreased mature B cell number ( J:174159 )

• dramatically reduced in the spleen

decreased B-1a cell number ( J:174159 )

• in the peritoneum

decreased marginal zone B cell number ( J:174159 )

decreased pre-B cell number ( J:174159 )

• small pre-B cells reduced in number in bone marrow

abnormal T cell number ( J:174159 )

decreased thymocyte number ( J:174159 )

• double negative thymocytes severely reduced

decreased double-positive T cell number ( J:174159 )

• double positive thymocytes severely reduced

decreased CD4-positive, alpha-beta T cell number ( J:174159 )

• reduced splenic populations

decreased CD8-positive, alpha-beta T cell number ( J:174159 )

• reduced splenic populations

spleen hypoplasia ( J:174159 )

• cell mass significantly reduced

decreased IgG2a level ( J:174159 )

• other immunoglobulin levels are normal

immune system

thymus hypoplasia ( J:174159 )

• cell mass significantly reduced

abnormal lymphocyte morphology ( J:174159 )

decreased pro-B cell number ( J:174159 )

• pre-pro and pro-B cells reduced in bone marrow

abnormal B cell number ( J:174159 )

increased follicular B cell number ( J:174159 )

• absolute numbers are somewhat increased

decreased B cell number ( J:174159 )

• 62% reduction in B220+ cells in bone marrow

• reduced in the spleen

• newly formed B cells are reduced in number in bone marrow

decreased immature B cell number ( J:174159 )

decreased transitional stage T1 B cell number ( J:174159 )

decreased transitional stage T2 B cell number ( J:174159 )

decreased mature B cell number ( J:174159 )

• dramatically reduced in the spleen

decreased B-1a cell number ( J:174159 )

• in the peritoneum

decreased marginal zone B cell number ( J:174159 )

decreased pre-B cell number ( J:174159 )

• small pre-B cells reduced in number in bone marrow

abnormal T cell number ( J:174159 )

decreased thymocyte number ( J:174159 )

• double negative thymocytes severely reduced

decreased double-positive T cell number ( J:174159 )

• double positive thymocytes severely reduced

decreased CD4-positive, alpha-beta T cell number ( J:174159 )

• reduced splenic populations

decreased CD8-positive, alpha-beta T cell number ( J:174159 )

• reduced splenic populations

spleen hypoplasia ( J:174159 )

• cell mass significantly reduced

decreased IgG2a level ( J:174159 )

• other immunoglobulin levels are normal

endocrine/exocrine glands

thymus hypoplasia ( J:174159 )

• cell mass significantly reduced

decreased thymocyte number ( J:174159 )

• double negative thymocytes severely reduced