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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdcd10tm1.1Kwhi
targeted mutation 1.1, Kevin Whitehead
MGI:5052184
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pdcd10tm1.1Kwhi/Pdcd10tm1.1Kwhi involves: C57BL/6 MGI:5052325
cn2
 		Pdcd10tm1Kwhi/Pdcd10tm1.1Kwhi
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/? 		involves: C57BL/6 * CBA MGI:5052328


Genotype
MGI:5052325
hm1
Allelic
Composition		 Pdcd10tm1.1Kwhi/Pdcd10tm1.1Kwhi
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10tm1.1Kwhi mutation (0 available); any Pdcd10 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth arrest ( J:173947 )
• growth arrest at E8.0 after gastrulation but prior to establishment of circulation




Genotype
MGI:5052328
cn2
Allelic
Composition		 Pdcd10tm1Kwhi/Pdcd10tm1.1Kwhi
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/?
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10tm1.1Kwhi mutation (0 available); any Pdcd10 mutation (19 available)
Pdcd10tm1Kwhi mutation (0 available); any Pdcd10 mutation (19 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:173947 )
• increased early mortality

cardiovascular system
abnormal brain vasculature morphology ( J:173947 )
• cerebral cavernous malformations develop by one month after tamoxifen treatment at 1 day of age
• additional abnormalities include capillary telangiectasias, isolated caverns and multiple back to back caverns, thrombosis, hemorrhage, formation of secondary channels
• attenuation of endothelial cells in larger secondary channels but no gaps
abnormal pericyte morphology ( J:173947 )
• foot processes are missing

nervous system
abnormal brain vasculature morphology ( J:173947 )
• cerebral cavernous malformations develop by one month after tamoxifen treatment at 1 day of age
• additional abnormalities include capillary telangiectasias, isolated caverns and multiple back to back caverns, thrombosis, hemorrhage, formation of secondary channels
• attenuation of endothelial cells in larger secondary channels but no gaps
abnormal astrocyte morphology ( J:173947 )
• foot processes are missing
CNS inflammation ( J:173947 )
• foci of mononuclear inflammatory cells also seen

immune system
CNS inflammation ( J:173947 )
• foci of mononuclear inflammatory cells also seen

cellular
abnormal astrocyte morphology ( J:173947 )
• foot processes are missing

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cerebral cavernous malformation 3 DOID:0060671 OMIM:603285
 J:173947




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory