Phenotypes associated with this allele

• Allele Symbol: Lgals2^tm1.1Cfg
• Allele Name: targeted mutation 1.1, Consortium for Functional Glycomics
• Allele ID: MGI:5052166
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lgals2^tm1.1Cfg/Lgals2^tm1.1Cfg	involves: C57BL/6	MGI:5615618

Genotype
MGI:5615618

hm1

• Allelic Composition: Lgals2^tm1.1Cfg/Lgals2^tm1.1Cfg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased neutrophil cell number ( J:217719 )

increased leukocyte cell number ( J:217719 )

• Cd11b+ cells in the Peyer's patch

increased lymphocyte cell number ( J:217719 )

increased T cell number ( J:217719 )

• CD3+ CD62L+ cells in the blood

• higher frequency of TCR-Vbeta staining in the lymph node

increased CD4-positive, alpha-beta T cell number ( J:217719 )

• slight in the spleen

increased CD8-positive, alpha-beta T cell number ( J:217719 )

• in the lymph node

increased spleen red pulp amount ( J:217719 )

abnormal immune system physiology ( J:217719 )

• lower levels of apoptosis in the lymph node compared with wild-type mice

increased IgG2b level ( J:217719 )

• in T-dependent and T-independent antibody responses

increased IgG3 level ( J:217719 )

• in T-dependent and T-independent antibody responses

increased susceptibility to type IV hypersensitivity reaction ( J:217719 )

enhanced humoral immune response ( J:217719 )

• T-dependent and T-independent

digestive/alimentary system

abnormal intestine physiology ( J:217719 )

• increased colon mucin amounts in half of mice

cellular

decreased apoptosis ( J:217719 )

• lower levels of apoptosis in the lymph node compared with wild-type mice

hematopoietic system

decreased neutrophil cell number ( J:217719 )

increased leukocyte cell number ( J:217719 )

• Cd11b+ cells in the Peyer's patch

increased lymphocyte cell number ( J:217719 )

increased T cell number ( J:217719 )

• CD3+ CD62L+ cells in the blood

• higher frequency of TCR-Vbeta staining in the lymph node

increased CD4-positive, alpha-beta T cell number ( J:217719 )

• slight in the spleen

increased CD8-positive, alpha-beta T cell number ( J:217719 )

• in the lymph node

increased spleen red pulp amount ( J:217719 )

increased IgG2b level ( J:217719 )

• in T-dependent and T-independent antibody responses

increased IgG3 level ( J:217719 )

• in T-dependent and T-independent antibody responses