Phenotypes associated with this allele

• Allele Symbol: Clec4e^tm1.1Cfg
• Allele Name: targeted mutation 1.1, Consortium for Functional Glycomics
• Allele ID: MGI:5052164
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec4e^tm1.1Cfg/Clec4e^tm1.1Cfg	B6.Cg-Clec4e^tm1.1Cfg	MGI:3797016

Genotype
MGI:3797016

hm1

• Allelic Composition: Clec4e^tm1.1Cfg/Clec4e^tm1.1Cfg
• Genetic Background: B6.Cg-Clec4e^tm1.1Cfg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased neutrophil cell number ( J:136334 )

• circulating neutrophil numbers are 25% lower than in controls though the authors note the numbers are within the normal range for C57BL/6 mice

decreased lymphocyte cell number ( J:136334 )

• circulating lymphocyte numbers are 19% lower than in controls though the authors note that the numbers are within the normal range for C57BL/6 mice

decreased monocyte cell number ( J:136334 )

• circulating monocyte numbers are 15% lower than in controls though the authors note that the numbers are within the normal range for C57BL/6 mice

abnormal macrophage physiology ( J:136334 )

• bone marrow-derived macrophages produce 25-30% less TNF 2 hours after incubation with candida albicans extract

decreased tumor necrosis factor secretion ( J:136334 )

• bone marrow-derived macrophages produce 25-30% less TNF 2 hours after incubation with candida albicans extract

increased susceptibility to fungal infection ( J:136334 )

• the magnitude of fungal burden in the kidney is several logs greater 5 days after systemic infcetion with candida albicans

cardiovascular system

abnormal heart morphology ( J:136334 )

• globular

abnormal heart valve morphology ( J:136334 )

• in 12 of 14 mice heart valves have extra increased amounts of extracellular matrix that result in globular endings of the valve leaflets

hematopoietic system

decreased neutrophil cell number ( J:136334 )

• circulating neutrophil numbers are 25% lower than in controls though the authors note the numbers are within the normal range for C57BL/6 mice

decreased lymphocyte cell number ( J:136334 )

• circulating lymphocyte numbers are 19% lower than in controls though the authors note that the numbers are within the normal range for C57BL/6 mice

decreased monocyte cell number ( J:136334 )

• circulating monocyte numbers are 15% lower than in controls though the authors note that the numbers are within the normal range for C57BL/6 mice

abnormal macrophage physiology ( J:136334 )

• bone marrow-derived macrophages produce 25-30% less TNF 2 hours after incubation with candida albicans extract