Phenotypes associated with this allele

• Allele Symbol: Sfrp4^tm1.1Blan
• Allele Name: targeted mutation 1.1, Beate Lanske
• Allele ID: MGI:5052054
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan	involves: C57BL/6	MGI:5052062
hm2	Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan	Not Specified	MGI:5790177
ht3	Sfrp4^tm1.1Blan/Sfrp4^+	Not Specified	MGI:5790179
cx4	Fgf23^tm1Blan/Fgf23^tm1Blan Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan	involves: 129 * C57BL/6	MGI:5052063
cx5	Kl^tm1Lex/Kl^tm1Lex Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan	involves: 129S/SvEvBrd * C57BL/6	MGI:5052065

Genotype
MGI:5052062

hm1

• Allelic Composition: Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced female fertility ( J:173962 )

♀ • female mice produced slightly smaller litters compared with heterozygous mice

decreased litter size ( J:173962 )

• female mice produced slightly smaller litters compared with heterozygous mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:173962 )

N • mice exhibit normal serum phosphate and calcium levels and urinary phosphate/creatinine levels

growth/size/body

growth/size/body region phenotype ( J:173962 )

N • mice exhibit normal body size

Genotype
MGI:5790177

hm2

• Allelic Composition: Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan
• Genetic Background: Not Specified

skeleton

increased osteoclast cell number ( J:234467 )

• the number of osteoclasts is increased along the diaphyseal endocortical surface

• however, number of osteoclasts is normal in trabecular bone

• in 8 day growing mice, the number of osteoclasts along the endosteum is increased

abnormal long bone metaphysis morphology ( J:234467 )

• expanded metaphyses

increased diameter of long bones ( J:234467 )

• width of bones at the midshaft is increased

increased trabecular bone volume ( J:234467 )

decreased compact bone thickness ( J:234467 )

• thin cortical bone in femora and tibiae in 2 week old mice

• thin cortical bone in the calvaria

• treatment with a sclerostin-neutralizing antibody increases cortical bone thickness

decreased femur compact bone thickness ( J:234467 )

abnormal bone ossification ( J:234467 )

• decrease in cortical bone formation

abnormal bone mineralization ( J:234467 )

• rates of periosteal and endocortical mineral apposition are equally reduced

increased bone ossification ( J:234467 )

• increase in bone-formation rates

abnormal bone remodeling ( J:234467 )

• failure of bone remodeling during growth

increased bone resorption ( J:234467 )

• increase in endocortical bone resorption

decreased bone strength ( J:234467 )

• reduction in mechanical strength measured at the diaphysis

hematopoietic system

increased osteoclast cell number ( J:234467 )

• the number of osteoclasts is increased along the diaphyseal endocortical surface

• however, number of osteoclasts is normal in trabecular bone

• in 8 day growing mice, the number of osteoclasts along the endosteum is increased

immune system

increased osteoclast cell number ( J:234467 )

• the number of osteoclasts is increased along the diaphyseal endocortical surface

• however, number of osteoclasts is normal in trabecular bone

• in 8 day growing mice, the number of osteoclasts along the endosteum is increased

limbs/digits/tail

decreased femur compact bone thickness ( J:234467 )

Genotype
MGI:5790179

ht3

• Allelic Composition: Sfrp4^tm1.1Blan/Sfrp4⁺
• Genetic Background: Not Specified

skeleton

increased trabecular bone volume ( J:234467 )

decreased compact bone thickness ( J:234467 )

• decrease in cortical thickness

• treatment with a soluble Bmp2 receptor, RAP-661, increases cortical bone thickness

abnormal bone mineralization ( J:234467 )

• rates of periosteal and endocortical mineral apposition are equally reduced

Genotype
MGI:5052063

cx4

• Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan; Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

premature death ( J:173962 )

• average life span is 8 to 12 weeks

homeostasis/metabolism

increased circulating phosphate level ( J:173962 )

renal/urinary system

nephrocalcinosis ( J:173962 )

respiratory system

emphysema ( J:173962 )

digestive/alimentary system

abnormal digestive system morphology ( J:173962 )

• mice exhibit intestinal atrophy unlike wild-type mice

cardiovascular system

calcified artery ( J:173962 )

growth/size/body

decreased body size ( J:173962 )

• at 3 and 6 weeks

Genotype
MGI:5052065

cx5

• Allelic Composition: Kl^tm1Lex/Kl^tm1Lex; Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

mortality/aging

premature death ( J:173962 )

• average life span is 14 to 16 weeks

homeostasis/metabolism

increased circulating phosphate level ( J:173962 )

digestive/alimentary system

abnormal digestive system morphology ( J:173962 )

• mice exhibit intestinal atrophy unlike wild-type mice

respiratory system

emphysema ( J:173962 )

renal/urinary system

nephrocalcinosis ( J:173962 )

cardiovascular system

calcified artery ( J:173962 )

growth/size/body

decreased body size ( J:173962 )

• at 3 and 6 weeks