About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rnase10tm1(cre)Hht
targeted mutation 1, Ilpo Huhtaniemi
MGI:5051834
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Artm1Verh/Y
Rnase10tm1(cre)Hht/Rnase10+ 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5051914


Genotype
MGI:5051914
cn1
Allelic
Composition		 Artm1Verh/Y
Rnase10tm1(cre)Hht/Rnase10+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1Verh mutation (1 available); any Ar mutation (22 available)
Rnase10tm1(cre)Hht mutation (0 available); any Rnase10 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
seminiferous tubule degeneration ( J:173897 )
• undergoing degeneration at 4 months
• germinal epithelium lost in many tubules
• intraepithelial cysts frequently found
enlarged testis ( J:173897 )
• at four months
• as a result of fluid retention
abnormal epididymis morphology ( J:173897 )
• spermatic granulomata frequently obstruct the epididymes
abnormal caput epididymis morphology ( J:173897 )
• initial segment hypoplasia by 30 days
• epididymis becomes obstructed at the level of the caput
• sperm build-up starting around 40 days causes severe dilation and finally, complete occlusion
abnormal epididymis epithelium morphology ( J:173897 )
• decreased height after 20-25 days in segments I and II
epididymis epithelium degeneration ( J:173897 )
• begins to degenerate distal to occlusion
testis inflammation ( J:173897 )
• some males develop unilateral orchitis
male infertility ( J:173897 )
• no pregnancies after mating to CD1 females
• vaginal plugs are produced

endocrine/exocrine glands
seminiferous tubule degeneration ( J:173897 )
• undergoing degeneration at 4 months
• germinal epithelium lost in many tubules
• intraepithelial cysts frequently found
enlarged testis ( J:173897 )
• at four months
• as a result of fluid retention
testis inflammation ( J:173897 )
• some males develop unilateral orchitis

immune system
testis inflammation ( J:173897 )
• some males develop unilateral orchitis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory