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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptgdstm1.1(cre)Gvn
targeted mutation 1.1, Marco Giovannini
MGI:5051626
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nf2tm2Gth/Nf2tm2Gth
Ptgdstm1.1(cre)Gvn/Ptgds+ 		involves: 129P2/OlaHsd * FVB/N MGI:5051641
cn2
 		Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Nf2tm2Gth/Nf2tm2Gth
Ptgdstm1.1(cre)Gvn/Ptgds+ 		involves: 129P2/OlaHsd * FVB/N MGI:5051643
cn3
 		Nf2tm2Gth/Nf2tm2Gth
Ptgdstm1.1(cre)Gvn/Ptgds+
Trp53tm1Brn/Trp53tm1Brn 		involves: 129P2/OlaHsd * FVB/N MGI:5051644
cn4
 		Ano3tm1.1Lyj/Ano3tm1.1Lyj
Ptgdstm1.1(cre)Gvn/Ptgds+ 		involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:6790233


Genotype
MGI:5051641
cn1
Allelic
Composition		 Nf2tm2Gth/Nf2tm2Gth
Ptgdstm1.1(cre)Gvn/Ptgds+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Ptgdstm1.1(cre)Gvn mutation (0 available); any Ptgds mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pituitary adenoma incidence ( J:173718 )
• observed in 69% of mice examined

mortality/aging
mortality/aging ( J:173718 )
N
• mice are born at normal Mendelian frequencies, are viable, and show comparable survival to control littermates (>75% survive to 10 months)

neoplasm
increased pituitary adenoma incidence ( J:173718 )
• observed in 69% of mice examined
increased meningioma incidence ( J:173718 )
• meningiomas are frequently observed; development is restricted to base of skull ventral to brainstem
increased osteoma incidence ( J:173718 )
• observed in 81% of mice examined

nervous system
increased pituitary adenoma incidence ( J:173718 )
• observed in 69% of mice examined
increased meningioma incidence ( J:173718 )
• meningiomas are frequently observed; development is restricted to base of skull ventral to brainstem

skeleton
increased osteoma incidence ( J:173718 )
• observed in 81% of mice examined




Genotype
MGI:5051643
cn2
Allelic
Composition		 Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Nf2tm2Gth/Nf2tm2Gth
Ptgdstm1.1(cre)Gvn/Ptgds+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1.1Brn mutation (1 available); any Cdkn2a mutation (62 available)
Nf2tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Ptgdstm1.1(cre)Gvn mutation (0 available); any Ptgds mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased meningioma incidence ( J:173718 )
• mice develop a slightly higher number of meningiomas (not statistically significant) relative to Cdkn2a-sufficient animals

mortality/aging
mortality/aging ( J:173718 )
N
• mice show similar survival/lifespan to Cdkn2a-sufficient animals

neoplasm
neoplasm ( J:173718 )
N
• no pituitary tumors are observed
increased meningioma incidence ( J:173718 )
• mice develop a slightly higher number of meningiomas (not statistically significant) relative to Cdkn2a-sufficient animals




Genotype
MGI:5051644
cn3
Allelic
Composition		 Nf2tm2Gth/Nf2tm2Gth
Ptgdstm1.1(cre)Gvn/Ptgds+
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Ptgdstm1.1(cre)Gvn mutation (0 available); any Ptgds mutation (15 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:173718 )
• survival is significantly shortened relative to Trp53-sufficient Nf2-deficient mice (almost complete mortality by about 7 months of age)

neoplasm
increased osteosarcoma incidence ( J:173718 )
• mice develop aggressive osteosarcomas early in life, likely reducing survival time
increased nervous system tumor incidence ( J:173718 )
• development of malignant peripheral nerve sheath tumours (MPNST) and choroid plexus carcinoma is also seen in some animals, likely reducing survival time

skeleton
increased osteosarcoma incidence ( J:173718 )
• mice develop aggressive osteosarcomas early in life, likely reducing survival time

nervous system
increased nervous system tumor incidence ( J:173718 )
• development of malignant peripheral nerve sheath tumours (MPNST) and choroid plexus carcinoma is also seen in some animals, likely reducing survival time




Genotype
MGI:6790233
cn4
Allelic
Composition		 Ano3tm1.1Lyj/Ano3tm1.1Lyj
Ptgdstm1.1(cre)Gvn/Ptgds+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano3tm1.1Lyj mutation (0 available); any Ano3 mutation (76 available)
Ptgdstm1.1(cre)Gvn mutation (0 available); any Ptgds mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
environmentally induced seizures ( J:310618 )
• P11 pups exhibit a greater susceptibility to hyperthermia-induced seizures
• however, mice show comparable susceptibility to chemoconvulsant-induced seizures

homeostasis/metabolism
abnormal body temperature homeostasis ( J:310618 )
• P11 mice exhibit a more rapid core temperature increase upon heat exposure
• P11 mice exhibit lower core temperature at ambient temperature of 22 or 30 degrees Celsius, but core temperature is comparable to wild-type controls when the ambient temperature is held at 37 degrees C
• the slopes of core temperature change with ambient temperature manipulation differs from controls

nervous system
environmentally induced seizures ( J:310618 )
• P11 pups exhibit a greater susceptibility to hyperthermia-induced seizures
• however, mice show comparable susceptibility to chemoconvulsant-induced seizures




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory