Phenotypes associated with this allele

• Allele Symbol: Gopc^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:5051001
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gopc^tm1a(EUCOMM)Wtsi/Gopc^tm1a(EUCOMM)Wtsi	C57BL/6-Gopc^tm1a(EUCOMM)Wtsi	MGI:5780806

Genotype
MGI:5780806

hm1

• Allelic Composition: Gopc^{tm1a(EUCOMM)Wtsi}/Gopc^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6-Gopc^{tm1a(EUCOMM)Wtsi}
• Cell Lines: EPD0822_2_B04

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:232679 )

• only very few homozygotes are produced from heterozygous intercrosses (3 homozygotes; 138 heterozygotes; 81 wild-type); time of lethality is not specified

cellular

abnormal cell physiology ( J:232679 )

• a significant reduction of beta1-adrenergic receptor levels is observed in hippocampal lysates, suggesting that Gopc stabilizes its interacting G-protein-coupled receptors