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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mitftm3.1Arnh
targeted mutation 3.1, Heinz Arnheiter
MGI:5050699
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mitftm3.1Arnh/Mitftm3.1Arnh involves: 129S6/SvEvTac * C57BL/6N MGI:5316882
cx2
 		Mitftm3.1Arnh/Mitftm3.1Arnh
Pax6Sey-Neu/Pax6+ 		involves: 129S6/SvEvTac * C57BL/6N MGI:5316883
cx3
 		Mitftm3.1Arnh/Mitftm3.1Arnh
Tg(PAX6)77Ndha/? 		involves: 129S6/SvEvTac * C57BL/6N * CBA MGI:5316884


Genotype
MGI:5316882
hm1
Allelic
Composition		 Mitftm3.1Arnh/Mitftm3.1Arnh
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitftm3.1Arnh mutation (0 available); any Mitf mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:188155 )
• mice appear grossly normal




Genotype
MGI:5316883
cx2
Allelic
Composition		 Mitftm3.1Arnh/Mitftm3.1Arnh
Pax6Sey-Neu/Pax6+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitftm3.1Arnh mutation (0 available); any Mitf mutation (72 available)
Pax6Sey-Neu mutation (1 available); any Pax6 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina pigment epithelium morphology ( J:188155 )
• dorsal thickening observed at E11.5 becoming prominent at E13.5
• trans-differentiating retinal pigment epithelium cells generate differentiated retinal cells by birth

pigmentation
abnormal retina pigment epithelium morphology ( J:188155 )
• dorsal thickening observed at E11.5 becoming prominent at E13.5
• trans-differentiating retinal pigment epithelium cells generate differentiated retinal cells by birth




Genotype
MGI:5316884
cx3
Allelic
Composition		 Mitftm3.1Arnh/Mitftm3.1Arnh
Tg(PAX6)77Ndha/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitftm3.1Arnh mutation (0 available); any Mitf mutation (72 available)
Tg(PAX6)77Ndha mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:188155 )
N
• no dorsal thickening of the retinal pigment epithelium observed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory