Phenotypes associated with this allele

• Allele Symbol: Eif2ak4^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5049871
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif2ak4^m1Btlr/Eif2ak4^m1Btlr	C57BL/6J-Eif2ak4^m1Btlr	MGI:5049878

Genotype
MGI:5049878

hm1

• Allelic Composition: Eif2ak4^m1Btlr/Eif2ak4^m1Btlr
• Genetic Background: C57BL/6J-Eif2ak4^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:173669 )

• macrophage exhibit increased susceptible to infection by the adenoviral vector Ad5-F16-GFP compared with wild-type cells

• however, mice exhibit normal IFN production following infection with Ad5-F16-GFP and normal susceptibility to infection with influenza and Rift Valley Fever Virus (RVFV)

• macrophage are moderately susceptible to MCMV infection and increased susceptibility to MCMV infection by intraperitoneal injection compared with wild-type cells

increased susceptibility to Adenoviridae infection ( J:173669 )

• macrophage exhibit increased susceptible to infection by the adenoviral vector Ad5-F16-GFP compared with wild-type cells

• however, mice exhibit normal IFN production following infection with Ad5-F16-GFP and normal susceptibility to infection with influenza and Rift Valley Fever Virus (RVFV)

increased susceptibility to Herpesvirales infection ( J:173669 )

• macrophage are moderately susceptible to MCMV infection and increased susceptibility to MCMV infection by intraperitoneal injection compared with wild-type

hematopoietic system

abnormal macrophage physiology ( J:173669 )

• macrophage exhibit increased susceptible to infection by the adenoviral vector Ad5-F16-GFP compared with wild-type cells

• however, mice exhibit normal IFN production following infection with Ad5-F16-GFP and normal susceptibility to infection with influenza and Rift Valley Fever Virus (RVFV)

• macrophage are moderately susceptible to MCMV infection and increased susceptibility to MCMV infection by intraperitoneal injection compared with wild-type cells