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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Usp4tm1Xilu
targeted mutation 1, Xiongbin Lu
MGI:5013819
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Usp4tm1Xilu/Usp4tm1Xilu B6.129-Usp4tm1Xilu MGI:5013824


Genotype
MGI:5013824
hm1
Allelic
Composition		 Usp4tm1Xilu/Usp4tm1Xilu
Genetic
Background		 B6.129-Usp4tm1Xilu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp4tm1Xilu mutation (0 available); any Usp4 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:173192 )
• mouse embryonic fibroblasts (MEFs) exhibit growth retardation and resistance against oncogenic transformation compared with wild-type cells
increased cellular sensitivity to ionizing radiation ( J:173192 )
• in mouse embryonic fibroblasts
increased thymocyte apoptosis ( J:173192 )
• induced by irradiation
increased splenocyte apoptosis ( J:173192 )
• induced by irradiation
early cellular replicative senescence ( J:173192 )
• in mouse embryonic fibroblasts

hematopoietic system
increased thymocyte apoptosis ( J:173192 )
• induced by irradiation
increased splenocyte apoptosis ( J:173192 )
• induced by irradiation

immune system
increased thymocyte apoptosis ( J:173192 )
• induced by irradiation
increased splenocyte apoptosis ( J:173192 )
• induced by irradiation

endocrine/exocrine glands
increased thymocyte apoptosis ( J:173192 )
• induced by irradiation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory