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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Panx1tm1.2Vmd
targeted mutation 1.2, Vishva M Dixit
MGI:5013648
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Panx1tm1.2Vmd/Panx1tm1.2Vmd C57BL/6N-Panx1tm1.2Vmd MGI:5013649


Genotype
MGI:5013649
hm1
Allelic
Composition		 Panx1tm1.2Vmd/Panx1tm1.2Vmd
Genetic
Background		 C57BL/6N-Panx1tm1.2Vmd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx1tm1.2Vmd mutation (0 available); any Panx1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:173213 )
N
• macrophage exhibit normal assembly of caspase-1-activating inflammosome complexes
abnormal T cell physiology ( J:173213 )
• thymocytes cultured with dexamethasone to induce apoptosis exhibit reduced YO-PRO-1 dye uptake and fail to release ATP unlike similarly treated wild-type cells
• apoptotic thymocytes fail to recruit macrophages in a transwell migration assay unlike wild-type cells
• however, thymocyte apoptosis is normal

hematopoietic system
abnormal T cell physiology ( J:173213 )
• thymocytes cultured with dexamethasone to induce apoptosis exhibit reduced YO-PRO-1 dye uptake and fail to release ATP unlike similarly treated wild-type cells
• apoptotic thymocytes fail to recruit macrophages in a transwell migration assay unlike wild-type cells
• however, thymocyte apoptosis is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory