Phenotypes associated with this allele

• Allele Symbol: Tg(Acp5-Adam8)#Rood
• Allele Name: transgene insertion, G David Roodman
• Allele ID: MGI:5009707
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Acp5-Adam8)#Rood/0	involves: BALB/c * C57BL/6	MGI:5009710

Genotype
MGI:5009710

tg1

• Allelic Composition: Tg(Acp5-Adam8)#Rood/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast morphology ( J:172936 )

• mice exhibit increased osteoclast surface to bone surface compared with wild-type mice

abnormal osteoclast differentiation ( J:172936 )

• CD11b+ marrow cells form increased number of osteoclasts and increased proliferation compared with wild-type bone marrow

increased osteoclast cell number ( J:172936 )

• CD11b+ marrow cells form increased number of osteoclasts and increased proliferation compared with wild-type bone marrow

decreased bone mineral density ( J:172936 )

decreased bone volume ( J:172936 )

abnormal trabecular bone morphology ( J:172936 )

• trabecular bone spacing is increased compared to in wild-type mice

increased bone resorption ( J:172936 )

immune system

abnormal osteoclast morphology ( J:172936 )

• mice exhibit increased osteoclast surface to bone surface compared with wild-type mice

abnormal osteoclast differentiation ( J:172936 )

• CD11b+ marrow cells form increased number of osteoclasts and increased proliferation compared with wild-type bone marrow

increased osteoclast cell number ( J:172936 )

• CD11b+ marrow cells form increased number of osteoclasts and increased proliferation compared with wild-type bone marrow

hematopoietic system

abnormal osteoclast morphology ( J:172936 )

• mice exhibit increased osteoclast surface to bone surface compared with wild-type mice

abnormal osteoclast differentiation ( J:172936 )

• CD11b+ marrow cells form increased number of osteoclasts and increased proliferation compared with wild-type bone marrow

increased osteoclast cell number ( J:172936 )

• CD11b+ marrow cells form increased number of osteoclasts and increased proliferation compared with wild-type bone marrow

cellular

abnormal osteoclast differentiation ( J:172936 )

• CD11b+ marrow cells form increased number of osteoclasts and increased proliferation compared with wild-type bone marrow