Phenotypes associated with this allele

• Allele Symbol: Adam8^tm1.1Rood
• Allele Name: targeted mutation 1.1, G David Roodman
• Allele ID: MGI:5009706
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam8^tm1.1Rood/Adam8^tm1.1Rood	involves: 129/Sv * C57BL/6 * FVB/N	MGI:5009709

Genotype
MGI:5009709

hm1

• Allelic Composition: Adam8^tm1.1Rood/Adam8^tm1.1Rood
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:172936 )

N • mice exhibit normal bone phenotype

abnormal osteoclast differentiation ( J:172936 )

• TNF-alpha-stimulated osteoclast differentiation is less than in wild-type mice

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:172936 )

• TNF-alpha-treated mice exhibit less osteoclast differentiation and calvarial fibrosis compared with similarly treated wild-type mice

immune system

abnormal osteoclast differentiation ( J:172936 )

• TNF-alpha-stimulated osteoclast differentiation is less than in wild-type mice

hematopoietic system

abnormal osteoclast differentiation ( J:172936 )

• TNF-alpha-stimulated osteoclast differentiation is less than in wild-type mice

cellular

abnormal osteoclast differentiation ( J:172936 )

• TNF-alpha-stimulated osteoclast differentiation is less than in wild-type mice