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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd22m1Btlr
mutation 1, Bruce Beutler
MGI:5009700
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd22m1Btlr/Cd22m1Btlr C57BL/6J-Cd22m1Btlr MGI:5009704
hm2
 		Cd22m1Btlr/Cd22m1Btlr involves: C57BL/6J MGI:5429184


Genotype
MGI:5009704
hm1
Allelic
Composition		 Cd22m1Btlr/Cd22m1Btlr
Genetic
Background		 C57BL/6J-Cd22m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22m1Btlr mutation (1 available); any Cd22 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:173079 )
• in peripheral B cells
abnormal humoral immune response ( J:173079 )
• aberrant T-independent antibody responses

hematopoietic system
abnormal B cell differentiation ( J:173079 )
• in peripheral B cells




Genotype
MGI:5429184
hm2
Allelic
Composition		 Cd22m1Btlr/Cd22m1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22m1Btlr mutation (1 available); any Cd22 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit a normal response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization

hematopoietic system
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory